Dynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex.
Publication Date
2022-01-12Journal Title
Nat Commun
ISSN
2041-1723
Publisher
Springer Science and Business Media LLC
Volume
13
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Apšvalka, D., Ferreira, C. S., Schmitz, T. W., Rowe, J., & Anderson, M. (2022). Dynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex.. Nat Commun, 13 (1) https://doi.org/10.1038/s41467-021-27926-w
Description
Funder: NIHR Cambridge Biomedical Research Centre, BRC-1215-20014
Abstract
Over the last two decades, inhibitory control has featured prominently in accounts of how humans and other organisms regulate their behaviour and thought. Previous work on how the brain stops actions and thoughts, however, has emphasised distinct prefrontal regions supporting these functions, suggesting domain-specific mechanisms. Here we show that stopping actions and thoughts recruits common regions in the right dorsolateral and ventrolateral prefrontal cortex to suppress diverse content, via dynamic targeting. Within each region, classifiers trained to distinguish action-stopping from action-execution also identify when people are suppressing their thoughts (and vice versa). Effective connectivity analysis reveals that both prefrontal regions contribute to action and thought stopping by targeting the motor cortex or the hippocampus, depending on the goal, to suppress their task-specific activity. These findings support the existence of a domain-general system that underlies inhibitory control and establish Dynamic Targeting as a mechanism enabling this ability.
Keywords
Article, /631/378/2649/2150, /631/378/1595/2639, /631/378/2632, /631/477/2811, /59/36, article
Sponsorship
Medical Research Council (MC_UU_00005/1)
Medical Research Council (MC_UU_00005/12)
Wellcome Trust (103838/Z/14/Z)
Identifiers
s41467-021-27926-w, 27926
External DOI: https://doi.org/10.1038/s41467-021-27926-w
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333009
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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