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dc.contributor.authorBatson, Carleen
dc.contributor.authorFroese, Logan
dc.contributor.authorGomez, Alwyn
dc.contributor.authorSainbhi, Amanjyot Singh
dc.contributor.authorStein, Kevin Y
dc.contributor.authorAlizadeh, Arsalan
dc.contributor.authorZeiler, Frederick A
dc.date.accessioned2022-01-28T14:39:59Z
dc.date.available2022-01-28T14:39:59Z
dc.date.issued2021
dc.identifier.issn2689-288X
dc.identifier.otherPMC8655816
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333017
dc.description.abstractAge and biological sex are two potential important modifiers of cerebrovascular reactivity post-traumatic brain injury (TBI) requiring close evaluation for potential subgroup responses. The goal of this study was to provide a preliminary exploratory analysis of the impact of age and biological sex on measures of cerebrovascular function in moderate/severe TBI. Forty-nine patients from the prospectively maintained TBI database at the University of Manitoba with archived high-frequency digital cerebral physiology were evaluated. Cerebrovascular reactivity indices were derived as follows: PRx (correlation between intracranial pressure [ICP] and mean arterial pressure [MAP]), PAx (correlation between pulse amplitude of ICP [AMP] and MAP), and RAC (correlation between AMP and cerebral perfusion pressure [CPP]). Time above clinically significant thresholds for each index was calculated over different periods of the acute intensive care unit stay. The association between PRx, PAx, and RAC measures with age was assessed using linear regression, and an age trichotomization scheme (<40, 40-60, >60) using Kruskal-Wallis testing. Similarly, association with biological sex was tested using Mann-Whitney U testing. Biological sex did not demonstrate an impact on any measures of cerebrovascular reactivity. Linear regression between age and PAx and RAC demonstrated a statistically significant positive linear relationship. Median PAx and RAC measures between trichotomized age categories demonstrated statistically significant increases with advancing age. The PRx failed to demonstrate any statistically significant relationship with age in this cohort, suggesting that in elderly patients with controlled ICP, PAx and RAC may be better metrics for detecting impaired cerebrovascular reactivity. Biological sex appears to not be associated with differences in cerebrovascular reactivity in this cohort. The PRx performed the worst in detecting impaired cerebrovascular reactivity in those with advanced age, where PAx and RAC appear to have excelled. Future work is required to validate these findings and explore the utility of different cerebrovascular reactivity indices.
dc.languageeng
dc.publisherMary Ann Liebert
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101773091
dc.sourceessn: 2689-288X
dc.subjectAging
dc.subjectSignal processing
dc.subjectCerebrovascular Reactivity
dc.subjectTbi
dc.subjectBiological Sex
dc.titleImpact of Age and Biological Sex on Cerebrovascular Reactivity in Adult Moderate/Severe Traumatic Brain Injury: An Exploratory Analysis.
dc.typeArticle
dc.date.updated2022-01-28T14:39:59Z
prism.endingPage501
prism.issueIdentifier1
prism.publicationNameNeurotrauma Rep
prism.startingPage488
prism.volume2
dc.identifier.doi10.17863/CAM.80441
rioxxterms.versionofrecord10.1089/neur.2021.0039
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidZeiler, Frederick A. [0000-0003-1737-0510]
dc.identifier.eissn2689-288X
cam.issuedOnline2021-11-09


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International