Peptide based drug delivery systems to the brain
Authors
Islam, Y
Leach, AG
Smith, J
Pluchino, S
Coxonl, CR
Sivakumaran, M
Downing, J
Fatokun, AA
Teixidò, M
Publication Date
2020Journal Title
Nano Express
ISSN
2632-959X
Publisher
IOP Publishing
Volume
1
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Islam, Y., Leach, A., Smith, J., Pluchino, S., Coxonl, C., Sivakumaran, M., Downing, J., et al. (2020). Peptide based drug delivery systems to the brain. Nano Express, 1 (1) https://doi.org/10.1088/2632-959X/ab9008
Abstract
Abstract: With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers and society at large. In the last two decades, numerous strategies and technologies have been developed and adapted to achieve drug penetration into the brain, evolving alongside our understanding of the physiological barriers between the brain and surrounding tissues. The blood brain barrier (BBB) has been known as the major barrier for drug delivery to the brain. Both invasive and minimally-invasive approaches have been investigated extensively, with the minimally-invasive approaches to drug delivery being more suitable. Peptide based brain targeting has been explored extensively in the last two decades. In this review paper, we focused on self-assembled peptides, shuttle peptides and nanoparticles drug delivery systems decorated/conjugated with peptides for brain penetration.
Keywords
Topical Review, blood brain barrier, drug delivery, brain, nanoparticles, nanotechnology, shuttle peptides
Identifiers
nanoxab9008, ab9008, nanox-100084.r1
External DOI: https://doi.org/10.1088/2632-959X/ab9008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333028
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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