Application of a Machine Learning Technology in the Definition of Metabolically Healthy and Unhealthy Status: A Retrospective Study of 2567 Subjects Suffering from Obesity with or without Metabolic Syndrome.
Authors
Masi, Davide
Biagi, Filippo
Vasquez Barahona, Daniel
Zilich, Rita
Gabrielli, Gabriele
Santin, Pierluigi
Gnessi, Lucio
Publication Date
2022-01-15Journal Title
Nutrients
ISSN
2072-6643
Publisher
MDPI AG
Volume
14
Issue
2
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Masi, D., Risi, R., Biagi, F., Vasquez Barahona, D., Watanabe, M., Zilich, R., Gabrielli, G., et al. (2022). Application of a Machine Learning Technology in the Definition of Metabolically Healthy and Unhealthy Status: A Retrospective Study of 2567 Subjects Suffering from Obesity with or without Metabolic Syndrome.. Nutrients, 14 (2) https://doi.org/10.3390/nu14020373
Abstract
The key factors playing a role in the pathogenesis of metabolic alterations observed in many patients with obesity have not been fully characterized. Their identification is crucial, and it would represent a fundamental step towards better management of this urgent public health issue. This aim could be accomplished by exploiting the potential of machine learning (ML) technology. In a single-centre study (n = 2567), we used an ML analysis to cluster patients with metabolically healthy (MHO) or metabolically unhealthy (MUO) obesity, based on several clinical and biochemical variables. The first model provided by ML was able to predict the presence/absence of MHO with an accuracy of 66.67% and 72.15%, respectively, and included the following parameters: HOMA-IR, upper body fat/lower body fat, glycosylated haemoglobin, red blood cells, age, alanine aminotransferase, uric acid, white blood cells, insulin-like growth factor 1 (IGF-1) and gamma-glutamyl transferase. For each of these parameters, ML provided threshold values identifying either MUO or MHO. A second model including IGF-1 zSDS, a surrogate marker of IGF-1 normalized by age and sex, was even more accurate with a 71.84% and 72.3% precision, respectively. Our results demonstrated high IGF-1 levels in MHO patients, thus highlighting a possible role of IGF-1 as a novel metabolic health parameter to effectively predict the development of MUO using ML technology.
Keywords
metabolic syndrome, insulin-like growth factor 1, artificial intelligence
Identifiers
External DOI: https://doi.org/10.3390/nu14020373
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333129
Rights
Licence:
https://creativecommons.org/licenses/by/4.0/
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