LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila.
Authors
Pérez-Moreno, Juan José
Santa-Cruz Mateos, Carmen
Martín-Bermudo, María Dolores
Estrada, Beatriz
Publication Date
2021Journal Title
Front Cell Dev Biol
ISSN
2296-634X
Publisher
Frontiers Media SA
Volume
9
Language
en
Type
Other
This Version
VoR
Metadata
Show full item recordCitation
Pérez-Moreno, J. J., Santa-Cruz Mateos, C., Martín-Bermudo, M. D., & Estrada, B. (2021). LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila.. [Other]. https://doi.org/10.3389/fcell.2021.749723
Abstract
Muscle development is a multistep process that involves cell specification, myoblast fusion, myotube migration, and attachment to the tendons. In spite of great efforts trying to understand the basis of these events, little is known about the molecular mechanisms underlying myotube migration. Knowledge of the few molecular cues that guide this migration comes mainly from studies in Drosophila. The migratory process of Drosophila embryonic muscles involves a first phase of migration, where muscle progenitors migrate relative to each other, and a second phase, where myotubes migrate searching for their future attachment sites. During this phase, myotubes form extensive filopodia at their ends oriented preferentially toward their attachment sites. This myotube migration and the subsequent muscle attachment establishment are regulated by cell adhesion receptors, such as the conserved proteoglycan Kon-tiki/Perdido. Laminins have been shown to regulate the migratory behavior of many cell populations, but their role in myotube migration remains largely unexplored. Here, we show that laminins, previously implicated in muscle attachment, are indeed required for muscle migration to tendon cells. Furthermore, we find that laminins genetically interact with kon-tiki/perdido to control both myotube migration and attachment. All together, our results uncover a new role for the interaction between laminins and Kon-tiki/Perdido during Drosophila myogenesis. The identification of new players and molecular interactions underlying myotube migration broadens our understanding of muscle development and disease.
Keywords
Cell and Developmental Biology, myogenesis, migration, adhesion, myotendinous junction (MTJ), drosophila, laminin, Kon-tiki, NG2
Identifiers
749723
External DOI: https://doi.org/10.3389/fcell.2021.749723
This record's DOI: https://doi.org/10.17863/CAM.80554
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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