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dc.contributor.authorIouranova, Alexandra
dc.contributor.authorGrun, Delphine
dc.contributor.authorRossy, Tamara
dc.contributor.authorDuc, Julien
dc.contributor.authorCoudray, Alexandre
dc.contributor.authorImbeault, Michael
dc.contributor.authorde Tribolet-Hardy, Jonas
dc.contributor.authorTurelli, Priscilla
dc.contributor.authorPersat, Alexandre
dc.contributor.authorTrono, Didier
dc.date.accessioned2022-01-28T16:35:06Z
dc.date.available2022-01-28T16:35:06Z
dc.date.issued2022-01-18
dc.date.submitted2021-06-24
dc.identifier.issn1759-8753
dc.identifier.others13100-021-00260-0
dc.identifier.other260
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333152
dc.descriptionFunder: schweizerischer nationalfonds zur förderung der wissenschaftlichen forschung; doi: http://dx.doi.org/10.13039/501100001711
dc.description.abstractBACKGROUND: Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to gene regulation in early human development and germ cells. RESULTS: Here, after studying genes driven by the long terminal repeat (LTR) of endogenous retroviruses, we identify the ape-restricted ZNF676 as the sequence-specific repressor of a subset of contemporary LTR12 integrants responsible for a large fraction of transpochimeric gene transcripts (TcGTs) generated during human early embryogenesis. We go on to reveal that the binding of this KZFP correlates with the epigenetic marking of these TEeRS in the germline, and is crucial to the control of genes involved in ciliogenesis/flagellogenesis, a biological process that dates back to the last common ancestor of eukaryotes. CONCLUSION: These results illustrate how KZFPs and their TE targets contribute to the evolutionary turnover of transcription networks and participate in the transgenerational inheritance of epigenetic traits.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectResearch
dc.titleKRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.
dc.typeArticle
dc.date.updated2022-01-28T16:35:05Z
prism.issueIdentifier1
prism.publicationNameMob DNA
prism.volume13
dc.identifier.doi10.17863/CAM.80575
dcterms.dateAccepted2021-12-23
rioxxterms.versionofrecord10.1186/s13100-021-00260-0
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidImbeault, Michael [0000-0002-0073-0922]
dc.contributor.orcidTrono, Didier [0000-0002-3383-0401]
dc.identifier.eissn1759-8753
pubs.funder-project-ideuropean research council (268721,694658)
cam.issuedOnline2022-01-18


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