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dc.contributor.authorKutwin, Magdalena
dc.contributor.authorMigdalska-Sęk, Monika
dc.contributor.authorBrzeziańska-Lasota, Ewa
dc.contributor.authorZelga, Piotr
dc.contributor.authorWoźniacka, Anna
dc.date.accessioned2022-01-28T16:47:47Z
dc.date.available2022-01-28T16:47:47Z
dc.date.issued2021-12-13
dc.identifier.issn2077-0383
dc.identifier.other34945130
dc.identifier.otherPMC8704681
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333325
dc.description.abstractBeing one of the most common dermatological inflammatory disorders, psoriasis is a frequent subject of research. It is considered to be a T cell-dependent immune disease whose pathogenesis is influenced by cytokines, such as IL-10, IL-17A, IL-17RA, IL-23A and IL-23R. The present study examines whether the expression of selected genes is correlated with the clinical course of psoriasis, assessed by the PASI, BSA and DLQI scales. Skin biopsies and blood from 60 patients with psoriasis and 24 healthy controls were obtained for RNA isolation. These were subjected to RT-PCR for IL-10, IL-17A, IL-17RA, IL-23A and IL-23R genes. The results were presented as an RQ value. IL-17A and IL-23R expression levels were higher in psoriatic skin compared to controls, while IL-10 expression was lower. A positive correlation was also found between RQ for IL-23A and PASI index. Psoriatic skin is characterised by elevated expression of IL-17A and IL-23R and decreased expression of IL-10. This indicates that the selected cytokines may be one of the factors involved in the pathogenesis and pathomechanism of psoriasis, but more studies need to be made before we can elucidate the exact reason for the unbalance in cytokine expression levels.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101606588
dc.sourceessn: 2077-0383
dc.subjectCytokines
dc.subjectMolecular markers
dc.subjectPsoriasis
dc.subjectimmunology
dc.subjectSkin Disease
dc.subjectDisease Activity
dc.titleAn Analysis of IL-10, IL-17A, IL-17RA, IL-23A and IL-23R Expression and Their Correlation with Clinical Course in Patients with Psoriasis.
dc.typeArticle
dc.date.updated2022-01-28T16:47:47Z
prism.issueIdentifier24
prism.publicationNameJ Clin Med
prism.volume10
dc.identifier.doi10.17863/CAM.80748
dcterms.dateAccepted2021-12-10
rioxxterms.versionofrecord10.3390/jcm10245834
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMigdalska-Sęk, Monika [0000-0002-9856-0764]
dc.contributor.orcidBrzeziańska-Lasota, Ewa [0000-0002-0882-1458]
dc.identifier.eissn2077-0383
pubs.funder-project-idMedical University of Lodz (503/1-152-01/503-11-002)
cam.issuedOnline2021-12-13


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International