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dc.contributor.authorPantaleão, Lucas C
dc.contributor.authorInzani, Isabella
dc.contributor.authorFurse, Samuel
dc.contributor.authorLoche, Elena
dc.contributor.authorHufnagel, Antonia
dc.contributor.authorAshmore, Thomas
dc.contributor.authorBlackmore, Heather L
dc.contributor.authorJenkins, Benjamin
dc.contributor.authorCarpenter, Asha AM
dc.contributor.authorWilczynska, Ania
dc.contributor.authorBushell, Martin
dc.contributor.authorKoulman, Albert
dc.contributor.authorTwinn, Denise
dc.contributor.authorOzanne, Susan
dc.date.accessioned2022-01-28T16:51:26Z
dc.date.available2022-01-28T16:51:26Z
dc.date.issued2022-01-13
dc.date.submitted2021-04-03
dc.identifier.issn2050-084X
dc.identifier.other69078
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333377
dc.description.abstractMaternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in late gestation E18.5 fetuses of diet-induced obese pregnant mice and established the changes in lipid abundance and fetal cardiac transcriptomics. We used untargeted and targeted lipidomics and transcriptomics to define changes in the serum and cardiac lipid composition and fatty acid metabolism in male and female fetuses. From these analyses we observed: (1) maternal obesity affects the maternal and fetal serum lipidome distinctly; (2) female fetal heart lipidomes are more sensitive to maternal obesity than males; (3) changes in lipid supply might contribute to early expression of lipolytic genes in mouse hearts exposed to maternal obesity. These results highlight the existence of sexually dimorphic responses of the fetal heart to the same in utero obesogenic environment and identify lipids species that might mediate programming of cardiovascular health.
dc.description.sponsorshipMRC Metabolic Diseases Unit [MRC_MC_UU_00014/4] Cambridge Home and EU Student Scholarship British Heart Foundation studentship [FS/12/64/30001] II was supported by a British Heart Foundation studentship [FS/18/56/35177]
dc.languageen
dc.publishereLife Sciences Publications Ltd
dc.subjectResearch Article
dc.subjectBiochemistry and Chemical Biology
dc.subjectDevelopmental Biology
dc.subjectmaternal obesity
dc.subjectfetal heart
dc.subjectheart metabolism
dc.subjectlipidomics
dc.subjecttranscriptomics
dc.subjectMouse
dc.titleMaternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex- dependent manner
dc.typeArticle
dc.date.updated2022-01-28T16:51:24Z
prism.publicationNameeLife
prism.volume11
dc.identifier.doi10.17863/CAM.80800
dcterms.dateAccepted2022-01-12
rioxxterms.versionofrecord10.7554/eLife.69078
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Mangoni, Arduino A
datacite.contributor.supervisorsenior_editor: Barton, Matthias
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.contributor.orcidTwinn, Denise [0000-0003-2610-277X]
dc.contributor.orcidOzanne, Susan [0000-0001-8753-5144]
dc.identifier.eissn2050-084X
pubs.funder-project-idBritish Heart Foundation (RG/17/12/33167)
pubs.funder-project-idWellcome Trust (208363/Z/17/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M027252/1)
pubs.funder-project-idMRC (MC_UU_00014/4)
cam.issuedOnline2022-01-13


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