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dc.contributor.authorNixon, Rebekah
dc.contributor.authorIp, Ting Hin Richard
dc.contributor.authorJenkins, Benjamin
dc.contributor.authorYip, Ping K
dc.contributor.authorClarke, Paul
dc.contributor.authorPonnusamy, Vennila
dc.contributor.authorMichael-Titus, Adina T
dc.contributor.authorKoulman, Albert
dc.contributor.authorShah, Divyen K
dc.date.accessioned2022-01-28T16:51:43Z
dc.date.available2022-01-28T16:51:43Z
dc.date.issued2021-11-28
dc.identifier.issn2072-6643
dc.identifier.other34959853
dc.identifier.otherPMC8703828
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333380
dc.description.abstractHypoxic-ischemic encephalopathy (HIE) is associated with perinatal brain injury, which may lead to disability or death. As the brain is a lipid-rich organ, various lipid species can be significantly impacted by HIE and these correlate with specific changes to the lipidomic profile in the circulation. Objective: To investigate the peripheral blood lipidomic signature in dried blood spots (DBS) from newborns with HIE. Using univariate analysis, multivariate analysis and sPLS-DA modelling, we show that newborns with moderate-severe HIE (n = 46) who underwent therapeutic hypothermia (TH) displayed a robust peripheral blood lipidomic signature comprising 29 lipid species in four lipid classes; namely phosphatidylcholine (PC), lysophosphatidylcholine (LPC), triglyceride (TG) and sphingomyelin (SM) when compared with newborns with mild HIE (n = 18). In sPLS-DA modelling, the three most discriminant lipid species were TG 50:3, TG 54:5, and PC 36:5. We report a reduction in plasma TG and SM and an increase in plasma PC and LPC species during the course of TH in newborns with moderate-severe HIE, compared to a single specimen from newborns with mild HIE. These findings may guide the research in nutrition-based intervention strategies after HIE in synergy with TH to enhance neuroprotection.
dc.description.sponsorshipNIHR Cambridge Biomedical Research Centre (146281) & Biotechnology and Biological Sciences Research Council (BB/P028195/1)
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101521595
dc.sourceessn: 2072-6643
dc.subjectBrain
dc.subjectLipids
dc.subjectNutrition
dc.subjectDried blood spot
dc.subjectNewborn
dc.subjectHypoxic-ischemic encephalopathy
dc.subjectTherapeutic Hypothermia
dc.subjectLipidome
dc.subjectHumans
dc.subjectHypoxia-Ischemia, Brain
dc.subjectHypothermia, Induced
dc.subjectInfant, Newborn
dc.subjectFemale
dc.subjectMale
dc.subjectDried Blood Spot Testing
dc.subjectLipidomics
dc.titleLipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy.
dc.typeArticle
dc.date.updated2022-01-28T16:51:42Z
prism.issueIdentifier12
prism.publicationNameNutrients
prism.volume13
dc.identifier.doi10.17863/CAM.80803
dcterms.dateAccepted2021-11-24
rioxxterms.versionofrecord10.3390/nu13124301
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidJenkins, Benjamin [0000-0003-0038-9709]
dc.contributor.orcidClarke, Paul [0000-0001-6203-7632]
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.identifier.eissn2072-6643
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P028195/1)
cam.issuedOnline2021-11-28


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International