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dc.contributor.authorVenter, Frank
dc.contributor.authorMatthews, Keith R.
dc.contributor.authorSilvester, Eleanor
dc.date.accessioned2022-01-31T10:13:05Z
dc.date.available2022-01-31T10:13:05Z
dc.date.issued2022-01-19
dc.date.submitted2021-09-29
dc.identifier.issn0962-8452
dc.identifier.otherrspb20212155
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333459
dc.description.abstractLaboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections with multiple disease agents. These interact with each other and with the host immune system dynamically, with disease outcomes affected by the composition of the community of infecting pathogens, their order of colonization, competition for niches and nutrients, and immune modulation. While pathogen-immune interactions have been detailed elsewhere, here we examine the use of ecological and experimental studies of trypanosome and malaria infections to discuss the interactions between pathogens in mammal hosts and arthropod vectors, including recently developed laboratory models for co-infection. The implications of pathogen co-infection for disease therapy are also discussed.
dc.languageen
dc.publisherThe Royal Society
dc.subjectPerspective
dc.subjectparasite
dc.subjectco-infection
dc.subjecttrypanosoma
dc.subjectplasmodium
dc.titleParasite co-infection: an ecological, molecular and experimental perspective
dc.typeArticle
dc.date.updated2022-01-31T10:13:04Z
prism.issueIdentifier1967
prism.publicationNameProceedings of the Royal Society B
prism.volume289
dc.identifier.doi10.17863/CAM.80883
dcterms.dateAccepted2021-12-09
rioxxterms.versionofrecord10.1098/rspb.2021.2155
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidVenter, Frank [0000-0002-1925-2510]
dc.contributor.orcidMatthews, Keith R. [0000-0003-0309-9184]
dc.contributor.orcidSilvester, Eleanor [0000-0001-9827-1412]
dc.identifier.eissn1471-2954
pubs.funder-project-idWellcome Trust (103740/Z/14/Z, 108905/B/15/Z, 221717/Z/20/Z)


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