The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping.
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Authors
Beresford-Jones, Benjamin S
Forster, Samuel C
Stares, Mark D
Notley, George
Viciani, Elisa
Browne, Hilary P
Boehmler, Daniel J
Soderholm, Amelia T
Kumar, Nitin
Vervier, Kevin
Cross, Justin R
Almeida, Alexandre
Lawley, Trevor D
Pedicord, Virginia A
Publication Date
2022-01-12Journal Title
Cell Host Microbe
ISSN
1931-3128
Publisher
Elsevier BV
Volume
30
Issue
1
Pages
124-138.e8
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Beresford-Jones, B. S., Forster, S. C., Stares, M. D., Notley, G., Viciani, E., Browne, H. P., Boehmler, D. J., et al. (2022). The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping.. Cell Host Microbe, 30 (1), 124-138.e8. https://doi.org/10.1016/j.chom.2021.12.003
Description
Funder: Royal Society
Abstract
Human health and disease have increasingly been shown to be impacted by the gut microbiota, and mouse models are essential for investigating these effects. However, the compositions of human and mouse gut microbiotas are distinct, limiting translation of microbiota research between these hosts. To address this, we constructed the Mouse Gastrointestinal Bacteria Catalogue (MGBC), a repository of 26,640 high-quality mouse microbiota-derived bacterial genomes. This catalog enables species-level analyses for mapping functions of interest and identifying functionally equivalent taxa between the microbiotas of humans and mice. We have complemented this with a publicly deposited collection of 223 bacterial isolates, including 62 previously uncultured species, to facilitate experimental investigation of individual commensal bacteria functions in vitro and in vivo. Together, these resources provide the ability to identify and test functionally equivalent members of the host-specific gut microbiotas of humans and mice and support the informed use of mouse models in human microbiota research.
Keywords
Butyrate, Gut Microbiota, Mouse Models, Commensal Bacteria, Public Database, Bacteria Culture Collection, Functionally Equivalent Species, Microbial Drug Metabolism, Mouse Gut Metagenomes, Translation Between Mouse And Human
Sponsorship
Sir Henry Dale Fellowship jointly funded by Wellcome Trust and Royal Society [206245/Z/17/Z].
Rosetrees Trust [A2194].
Wellcome Trust [098051].
Funder references
Wellcome Trust (206245/Z/17/Z)
Rosetrees Trust (A2194)
Identifiers
34971560, PMC8763404
External DOI: https://doi.org/10.1016/j.chom.2021.12.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333486
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