Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression.
View / Open Files
Authors
Althubaity, Noha
Schubert, Julia
Martins, Daniel
Yousaf, Tayyabah
Nettis, Maria A
Mondelli, Valeria
Pariante, Carmine
Harrison, Neil A
Bullmore, Edward T
Dima, Danai
Turkheimer, Federico E
Veronese, Mattia
Publication Date
2022Journal Title
Neuroimage Clin
ISSN
2213-1582
Publisher
Elsevier BV
Volume
33
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Althubaity, N., Schubert, J., Martins, D., Yousaf, T., Nettis, M. A., Mondelli, V., Pariante, C., et al. (2022). Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression.. Neuroimage Clin, 33 https://doi.org/10.1016/j.nicl.2021.102926
Abstract
BACKGROUND: Recent studies have shown that choroid plexuses (CP) may be involved in the neuro-immune axes, playing a role in the interaction between the central and peripheral inflammation. Here we aimed to investigate CP volume alterations in depression and their associations with inflammation. METHODS: 51 depressed participants (HDRS score > 13) and 25 age- and sex-matched healthy controls (HCs) from the Wellcome Trust NIMA consortium were re-analysed for the study. All the participants underwent full peripheral cytokine profiling and simultaneous [11C]PK11195 PET/structural MRI imaging for measuring neuroinflammation and CP volume respectively. RESULTS: We found a significantly greater CP volume in depressed subjects compared to HCs (t(76) = +2.17) that was positively correlated with [11C]PK11195 PET binding in the anterior cingulate cortex (r = 0.28, p = 0.02), prefrontal cortex (r = 0.24, p = 0.04), and insular cortex (r = 0.24, p = 0.04), but not with the peripheral inflammatory markers: CRP levels (r = 0.07, p = 0.53), IL-6 (r = -0.08, p = 0.61), and TNF-α (r = -0.06, p = 0.70). The CP volume correlated with the [11C]PK11195 PET binding in CP (r = 0.34, p = 0.005). Integration of transcriptomic data from the Allen Human Brain Atlas with the brain map depicting the correlations between CP volume and PET imaging found significant gene enrichment for several pathways involved in neuroinflammatory response. CONCLUSION: This result supports the hypothesis that changes in brain barriers may cause reduction in solute exchanges between blood and CSF, disturbing the brain homeostasis and ultimately contributing to inflammation in depression. Given that CP anomalies have been recently detected in other brain disorders, these results may not be specific to depression and might extend to other conditions with a peripheral inflammatory component.
Keywords
Blood brain barrier, Depression, neuroinflammation, Choroid Plexus
Sponsorship
Wellcome Trust (104025/Z/14/Z)
Medical Research Council (MC_G0802534)
Medical Research Council (MR/M009041/1)
Identifiers
34972034, PMC8718974
External DOI: https://doi.org/10.1016/j.nicl.2021.102926
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333488
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk