ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis.

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Authors
Jakobczyk, Hélène
  Jiang, Yan
  Debaize, Lydie
Soubise, Benoit
Avner, Stéphane
Sérandour, Aurélien A
Rouger-Gaudichon, Jérémie
Publication Date
2022-02
Journal Title
Leukemia
ISSN
0887-6924
Publisher
Springer Science and Business Media LLC
Volume
36
Issue
2
Pages
549-554
Language
en
Type
Article
This Version
VoR
Metadata
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Citation
Jakobczyk, H., Jiang, Y., Debaize, L., Soubise, B., Avner, S., Sérandour, A. A., Rouger-Gaudichon, J., et al. (2022). ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis.. Leukemia, 36 (2), 549-554. https://doi.org/10.1038/s41375-021-01409-9
Description
Funder: Société Française de Biochimie et Biologie Moléculaire ; French Research Ministry
Funder: Cancéropole Grand Ouest ; Région Bretagne ; Société Française d’Hématologie
Funder: Ligue Régionale contre le cancer ;
Abstract
ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression.
Keywords
Letter, /631/67/1990/283, /692/699/1541, /13/31, /96/106, /96/1, /82/80, /96/109, /45/77, /45/44, letter
Identifiers
s41375-021-01409-9, 1409
External DOI: https://doi.org/10.1038/s41375-021-01409-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333508
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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