Cell-free DNA technologies for the analysis of brain cancer.
Publication Date
2022-02Journal Title
Br J Cancer
ISSN
0007-0920
Publisher
Springer Science and Business Media LLC
Volume
126
Issue
3
Pages
371-378
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Mair, R., & Mouliere, F. (2022). Cell-free DNA technologies for the analysis of brain cancer.. Br J Cancer, 126 (3), 371-378. https://doi.org/10.1038/s41416-021-01594-5
Abstract
Survival for glioma patients has shown minimal improvement over the past 20 years. The ability to detect and monitor gliomas relies primarily upon imaging technologies that lack sensitivity and specificity, especially during the post-surgical treatment phase. Treatment-response monitoring with an effective liquid-biopsy paradigm may also provide the most facile clinical scenario for liquid-biopsy integration into brain-tumour care. Conceptually, liquid biopsy is advantageous when compared with both tissue sampling (less invasive) and imaging (more sensitive and specific), but is hampered by technical and biological problems. These problems predominantly relate to low concentrations of tumour-derived DNA in the bloodstream of glioma patients. In this review, we highlight methods by which the neuro-oncological scientific and clinical communities have attempted to circumvent this limitation. The use of novel biological, technological and computational approaches will be explored. The utility of alternate bio-fluids, tumour-guided sequencing, epigenomic and fragmentomic methods may eventually be leveraged to provide the biological and technological means to unlock a wide range of clinical applications for liquid biopsy in glioma.
Keywords
Review Article, /631/67/1922, /631/61/514/2254, /692/53, review-article
Sponsorship
KWF Kankerbestrijding (Dutch Cancer Society) (12822)
Identifiers
s41416-021-01594-5, 1594
External DOI: https://doi.org/10.1038/s41416-021-01594-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333560
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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