Transition metal mediated bioorthogonal release
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Publication Date
2022-01Journal Title
Chem Catalysis
ISSN
2667-1107
Publisher
Elsevier BV
Volume
2
Issue
1
Pages
39-51
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Sabatino, V., Unnikrishnan, V., & Bernardes, G. (2022). Transition metal mediated bioorthogonal release. Chem Catalysis, 2 (1), 39-51. https://doi.org/10.1016/j.checat.2021.12.007
Abstract
Bioorthogonal chemistry offers powerful tools to study and manipulate biological systems without interfering with the biological processes. Of paramount interest is the possibility to exploit bioorthogonal tools to deliver novel therapeutic applications. Bioorthogonal prodrug activation is one of the most exciting areas of research and is currently progressing towards phase I clinical trials. Despite their limitations in biological media, transition metal catalysts have been engineered to enact abiotic cofactors and trigger bond-breaking reactions widely employed for the release of small molecules from masking groups. Herein, we highlight the challenges and opportunities of metal-mediated bioorthogonal cleavage reactions for the release of cargo molecules and other emerging applications such as protein activation and RNA degradation.
Sponsorship
Marie Skłodowska-Curie Grant Agreement No. 859908. The authors also thank the Swiss National Science Foundation (Postdoc.Mobility fellowship to V.S.) and FCT Portugal (Stimulus Grant CEECIND/00453/2018 to G.J.L.B.)
Funder references
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (859908)
Identifiers
External DOI: https://doi.org/10.1016/j.checat.2021.12.007
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333575
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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