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dc.contributor.authorSabatino, V
dc.contributor.authorUnnikrishnan, VB
dc.contributor.authorBernardes, GJL
dc.date.accessioned2022-02-03T00:30:17Z
dc.date.available2022-02-03T00:30:17Z
dc.date.issued2022-01
dc.identifier.issn2667-1107
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333575
dc.description.abstractBioorthogonal chemistry offers powerful tools to study and manipulate biological systems without interfering with the biological processes. Of paramount interest is the possibility to exploit bioorthogonal tools to deliver novel therapeutic applications. Bioorthogonal prodrug activation is one of the most exciting areas of research and is currently progressing towards phase I clinical trials. Despite their limitations in biological media, transition metal catalysts have been engineered to enact abiotic cofactors and trigger bond-breaking reactions widely employed for the release of small molecules from masking groups. Herein, we highlight the challenges and opportunities of metal-mediated bioorthogonal cleavage reactions for the release of cargo molecules and other emerging applications such as protein activation and RNA degradation.
dc.description.sponsorshipMarie Skłodowska-Curie Grant Agreement No. 859908. The authors also thank the Swiss National Science Foundation (Postdoc.Mobility fellowship to V.S.) and FCT Portugal (Stimulus Grant CEECIND/00453/2018 to G.J.L.B.)
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleTransition metal mediated bioorthogonal release
dc.typeArticle
dc.publisher.departmentDepartment of Chemistry
dc.date.updated2022-02-01T15:54:29Z
prism.endingPage51
prism.issueIdentifier1
prism.publicationDate2022
prism.publicationNameChem Catalysis
prism.startingPage39
prism.volume2
dc.identifier.doi10.17863/CAM.80992
dcterms.dateAccepted2021-12-06
rioxxterms.versionofrecord10.1016/j.checat.2021.12.007
rioxxterms.versionAM
dc.contributor.orcidSabatino, V [0000-0002-0424-813X]
dc.identifier.eissn2667-1093
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (859908)
cam.issuedOnline2022-01-20
cam.orpheus.success2022-02-02 - Embargo set during processing via Fast-track
cam.depositDate2022-02-01
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-01-20


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International