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Transition metal mediated bioorthogonal release

Accepted version
Peer-reviewed

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Type

Article

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Authors

Unnikrishnan, VB 
Bernardes, GJL 

Abstract

Bioorthogonal chemistry offers powerful tools to study and manipulate biological systems without interfering with the biological processes. Of paramount interest is the possibility to exploit bioorthogonal tools to deliver novel therapeutic applications. Bioorthogonal prodrug activation is one of the most exciting areas of research and is currently progressing towards phase I clinical trials. Despite their limitations in biological media, transition metal catalysts have been engineered to enact abiotic cofactors and trigger bond-breaking reactions widely employed for the release of small molecules from masking groups. Herein, we highlight the challenges and opportunities of metal-mediated bioorthogonal cleavage reactions for the release of cargo molecules and other emerging applications such as protein activation and RNA degradation.

Description

Keywords

3402 Inorganic Chemistry, 34 Chemical Sciences, Biotechnology, Bioengineering

Journal Title

Chem Catalysis

Conference Name

Journal ISSN

2667-1107
2667-1093

Volume Title

2

Publisher

Elsevier BV
Sponsorship
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (859908)
Marie Skłodowska-Curie Grant Agreement No. 859908. The authors also thank the Swiss National Science Foundation (Postdoc.Mobility fellowship to V.S.) and FCT Portugal (Stimulus Grant CEECIND/00453/2018 to G.J.L.B.)