A finger on the pulse of regeneration: insights into the cellular mechanisms of adult digit tip regeneration.
Storer, Mekayla A
Miller, Freda D
Curr Opin Genet Dev
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Storer, M. A., & Miller, F. D. (2021). A finger on the pulse of regeneration: insights into the cellular mechanisms of adult digit tip regeneration.. Curr Opin Genet Dev, 70 1-6. https://doi.org/10.1016/j.gde.2021.04.002
In mammals, multi-tissue regeneration is largely restricted to the distal portion of the digit tip and involves the formation of a blastema, a transient, proliferating cell mass that reforms the diverse tissues of the digit. Historically little was known about the mammalian blastema but with recent advances in single cell transcriptomic approaches and genetic lineage tracing, a more precise understanding of this critical structure has begun to emerge. In this review we summarise the cellular mechanisms underlying adult mammalian digit tip regeneration. We posit that understanding how some mammals naturally regenerate complex tissues will lead to strategies for enhancing regenerative abilities in humans.
Wellcome Trust (203151/Z/16/Z)
Medical Research Council (MC_PC_17230)
External DOI: https://doi.org/10.1016/j.gde.2021.04.002
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333580
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/