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dc.contributor.authorValls, Pablo Oriol
dc.contributor.authorEsposito, Alessandro
dc.date.accessioned2022-02-03T00:30:41Z
dc.date.available2022-02-03T00:30:41Z
dc.date.issued2022-04
dc.identifier.issn0955-0674
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333581
dc.description.abstractCell signalling engenders cells with the capability to receive and process information from the intracellular and extracellular environments, trigger and execute biological responses, and communicate with each other. Ultimately, cell signalling is responsible for maintaining homeostasis at the cellular, tissue and systemic level. For this reason, cell signalling is a topic of intense research efforts aimed to elucidate how cells coordinate transitions between states in developing and adult organisms in physiological and pathological conditions. Here, we review current knowledge of how cell signalling operates at multiple spatial and temporal scales, focusing on how single-cell analytical techniques reveal mechanisms underpinning cell-to-cell variability, signalling plasticity, and collective cellular responses.
dc.description.sponsorshipA.E. acknowledges the financial support provided by the CRUK with a multi-disciplinary project award (OncoLive, C54674/A27487), pump-priming funds from the CRUK Cambridge Center (C9685/A25117, C9685/A28397). A.E. also acknowledges financial support from Medical Research Council program grants (MC_UU_12022/1 and MC_UU_12022/8) awarded to the MRC Cancer Unit. P.O.V. acknowledges the financial support of the MRC Doctoral Training Award (ref. 1753414) granted to the MRC Cancer Unit.
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleSignalling dynamics, cell decisions, and homeostatic control in health and disease.
dc.typeArticle
dc.publisher.departmentMrc Cancer Unit
dc.date.updated2022-02-02T12:33:55Z
prism.publicationNameCurr Opin Cell Biol
dc.identifier.doi10.17863/CAM.80998
dcterms.dateAccepted2022-01-28
rioxxterms.versionofrecord10.1016/j.ceb.2022.01.011
rioxxterms.versionAM
dc.contributor.orcidEsposito, Alessandro [0000-0002-5051-091X]
dc.identifier.eissn1879-0410
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idCancer Research UK (C54674/A27487)
pubs.funder-project-idCancer Research UK (A25117)
pubs.funder-project-idMRC (MC_UU_12022/8)
cam.orpheus.successWed Mar 23 10:26:28 GMT 2022 - Embargo updated
cam.orpheus.counter1
cam.depositDate2022-02-02
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-03-01


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International