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dc.contributor.authorZhang, Chencheng
dc.contributor.authorZhang, Yingying
dc.contributor.authorLuo, Huichun
dc.contributor.authorXu, Xinmeng
dc.contributor.authorYuan, Ti-Fei
dc.contributor.authorLi, Dianyou
dc.contributor.authorCai, Yi-Yun
dc.contributor.authorGong, Hengfen
dc.contributor.authorPeng, Dai-Hui
dc.contributor.authorFang, Yi-Ru
dc.contributor.authorVoon, Valerie
dc.contributor.authorSun, Bomin
dc.date.accessioned2022-02-03T16:35:08Z
dc.date.available2022-02-03T16:35:08Z
dc.date.issued2022-02-03
dc.date.submitted2021-06-22
dc.identifier.issn2158-3188
dc.identifier.others41398-022-01818-z
dc.identifier.other1818
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333604
dc.descriptionFunder: Shanghai Clinical Research Center for Mental Health (19MC1911100). SJTU Trans-med Awards Research (2019015) to BMS.
dc.descriptionFunder: Shanghai Clinical Research Center for Mental Health (19MC1911100). CCZ is supported by the fellowship of Shanghai Research Center for Brain Science and Brain-Inspired Technology.
dc.description.abstractDeep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward system has also been reported to alleviate depressive symptoms in patients with TRD or bipolar disorder (BD). In this pilot open-label prospective study, we explored the safety and clinical effectiveness of HB-DBS treatment in seven patients with TRD or BD. Also, local field potentials (LFPs) were recorded from the patients' left and right HB to explore the power and asymmetry of oscillatory activities as putative biomarkers of the underlying disease state. At 1-month follow-up (FU), depression and anxiety symptoms were both reduced by 49% (n = 7) along with substantial improvements in patients' health status, functional impairment, and quality of life. Although the dropout rate was high and large variability in clinical response existed, clinical improvements were generally maintained throughout the study [56%, 46%, and 64% reduction for depression and 61%, 48%, and 70% reduction for anxiety at 3-month FU (n = 5), 6-month FU (n = 5), and 12-month FU (n = 3), respectively]. After HB-DBS surgery, sustained improvements in mania symptoms were found in two patients who presented with mild hypomania at baseline. Another patient, however, experienced an acute manic episode 2 months after surgery that required hospitalization. Additionally, weaker and more symmetrical HB LFP oscillatory activities were associated with more severe depression and anxiety symptoms at baseline, in keeping with the hypothesis that HB dysfunction contributes to MDD pathophysiology. These preliminary findings indicate that HB-DBS may offer a valuable treatment option for depressive symptoms in patients who suffer from TRD or BD. Larger and well-controlled studies are warranted to examine the safety and efficacy of HB-DBS for treatment-refractory mood disorders in a more rigorous fashion.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/692/699
dc.subject/692/699/476/1414
dc.subjectarticle
dc.titleBilateral Habenula deep brain stimulation for treatment-resistant depression: clinical findings and electrophysiological features.
dc.typeArticle
dc.date.updated2022-02-03T16:35:08Z
prism.issueIdentifier1
prism.publicationNameTransl Psychiatry
prism.volume12
dc.identifier.doi10.17863/CAM.81020
dcterms.dateAccepted2022-01-13
rioxxterms.versionofrecord10.1038/s41398-022-01818-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidZhang, Chencheng [0000-0003-4472-4134]
dc.contributor.orcidZhang, Yingying [0000-0002-0408-1632]
dc.contributor.orcidYuan, Ti-Fei [0000-0003-0510-715X]
dc.contributor.orcidFang, Yi-Ru [0000-0002-8748-9085]
dc.contributor.orcidVoon, Valerie [0000-0001-6790-1776]
dc.contributor.orcidSun, Bomin [0000-0001-5931-2197]
dc.identifier.eissn2158-3188
cam.issuedOnline2022-02-03


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