High frequency of psychosis in late-stage Parkinsońs disease.
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Authors
Chendo, Inês
Fabbri, Margherita
Godinho, Catarina
Moiron Simões, Rita
Severiano Sousa, Catarina
Coelho, Miguel
Ferreira, Joaquim J
Publication Date
2021Journal Title
Clin Park Relat Disord
ISSN
2590-1125
Publisher
Elsevier BV
Volume
5
Number
100119
Pages
100119
Type
Article
This Version
VoR
Physical Medium
Electronic-eCollection
Metadata
Show full item recordCitation
Chendo, I., Fabbri, M., Godinho, C., Moiron Simões, R., Severiano Sousa, C., Coelho, M., Voon, V., & et al. (2021). High frequency of psychosis in late-stage Parkinsońs disease.. Clin Park Relat Disord, 5 (100119), 100119. https://doi.org/10.1016/j.prdoa.2021.100119
Abstract
BACKGROUND: Psychosis is a frequent non-motor symptom in Parkinson's disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited.This study aimed to determine the frequency of psychosis in LSPD patients through clinical diagnostic interview (CDI) (gold standard), according to NINDS/NIMH diagnostic criteria for PDP. The secondary objectives were to characterize the phenomenology, to test selected instruments and assess their adequacy in comparison to CDI, and to assess the psychiatric comorbidities. METHODS: A cross-sectional study including LSPD patients (patients with ≥ 7 years from symptoms onset and Hoehn and Yahr scale score > 3 or a Schwab and England scale score < 50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Each patient was interviewed by a psychiatrist who performed a CDI. RESULTS: 92 LSPD patients were included. 55.4% experienced psychotic symptoms according to NINDS/NIMH diagnostic criteria for PDP. Hallucinations were present in 94.1% and delusions in 29.4% of the psychotic patients. Visual hallucinations were the most common (88.23%) psychotic symptom. 72.5% of LSPD patients with psychotic symptoms had at least one comorbid psychiatric diagnosis. Lower frequency of psychosis was found when the assessment was performed only through selected instruments rather than CDI. CONCLUSIONS: A high frequency (55.4%) of psychotic symptoms and comorbid psychiatric (72.5%) diagnosis were found in LSPD patients. The use of CDI, in addition to structured scales may increase the sensitivity of detecting psychotic symptoms.
Keywords
Late-stage, Parkinson’s disease, Psychiatric comorbidities, Psychosis
Sponsorship
Medical Research Council (MR/P008747/1)
Identifiers
External DOI: https://doi.org/10.1016/j.prdoa.2021.100119
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333624
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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