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dc.contributor.authorMurray, Aja L
dc.contributor.authorEisner, Manuel
dc.contributor.authorNagin, Daniel
dc.contributor.authorRibeaud, Denis
dc.date.accessioned2022-02-04T16:16:30Z
dc.date.available2022-02-04T16:16:30Z
dc.date.issued2022-01
dc.date.submitted2020-06-03
dc.identifier.issn1018-8827
dc.identifier.others00787-020-01679-1
dc.identifier.other1679
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333649
dc.descriptionFunder: Jacobs Foundation; doi: http://dx.doi.org/10.13039/501100003986
dc.descriptionFunder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; doi: http://dx.doi.org/10.13039/501100001711
dc.descriptionFunder: University of Edinburgh
dc.description.abstractDevelopmental trajectories of mental health issues can often be usefully summarised in a small number of clinically meaningful subtypes. Given the high levels of heterotypic and homotypic comorbidity in child and adolescent mental health symptoms, we explored whether it was possible to identify clinically meaningful developmental subtypes of multiple commonly co-occurring mental health issues. We evaluated the combined developmental trajectories of the most common and commonly co-occurring child and adolescent mental health issues: attention-deficit/hyperactivity disorder (ADHD), internalising, and externalising symptoms in a normative sample of youth with data (n = 1620) at ages 7, 8, 9, 10, 11, 12, 13 and 15 using group-based multi-trajectory modelling. Multinomial logistic regression was used to evaluate predictors of group membership. Our optimal model included six trajectory groups, labelled 'unaffected', 'normative maturing', 'internalising', 'multimorbid late onset', 'multimorbid remitting', and 'multimorbid with remitting externalising'. Examining covariates of group membership suggested that males and bully victims tend to have complex mental health profiles; academic achievement and smoking during pregnancy have general associations with mental health irrespective of symptom developmental trajectories or combination; and maternal post-natal depression is primarily related to symptoms that are already in evidence by the beginning of the school years. Results suggest that developmental trajectories of commonly co-occurring mental health issues can be usefully summarised in terms of a small number of developmental subtypes. These subtypes more often than not involve multiple co-occurring mental health issues. Their association with mental health covariates depends on the combination and developmental timing of symptoms in ways that suggest they can be clinically informative.
dc.description.sponsorshipFunding from the Jacobs Foundation and Swiss National Science Foundation are gratefully acknowledged.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectOriginal Contribution
dc.subjectComorbidity
dc.subjectDevelopmental trajectories
dc.subjectGroup-based trajectory modelling
dc.subjectAttention-deficit/hyperactivity disorder
dc.subjectInternalising problems
dc.subjectExternalising problems
dc.titleA multi-trajectory analysis of commonly co-occurring mental health issues across childhood and adolescence.
dc.typeArticle
dc.date.updated2022-02-04T16:16:29Z
prism.endingPage159
prism.issueIdentifier1
prism.publicationNameEur Child Adolesc Psychiatry
prism.startingPage145
prism.volume31
dc.identifier.doi10.17863/CAM.81067
dcterms.dateAccepted2020-10-28
rioxxterms.versionofrecord10.1007/s00787-020-01679-1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidEisner, Manuel [0000-0001-5436-9282]
dc.identifier.eissn1435-165X
pubs.funder-project-idJacobs Foundation (unknown)
cam.issuedOnline2020-11-16


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