Donor-Transmitted Cancer in Orthotopic Solid Organ Transplant Recipients: A Systematic Review
Authors
Greenhall, George H. B.
Ibrahim, Maria
Dutta, Utkarsh
Doree, Carolyn
Brunskill, Susan J.
Johnson, Rachel J.
Tomlinson, Laurie A.
Callaghan, Chris J.
Watson, Christopher J. E.
Publication Date
2022-02-04Journal Title
Transplant International
Publisher
Frontiers Media S.A.
Volume
35
Language
en
Type
Other
This Version
VoR
Metadata
Show full item recordCitation
Greenhall, G. H. B., Ibrahim, M., Dutta, U., Doree, C., Brunskill, S. J., Johnson, R. J., Tomlinson, L. A., et al. (2022). Donor-Transmitted Cancer in Orthotopic Solid Organ Transplant Recipients: A Systematic Review. [Other]. https://doi.org/10.3389/ti.2021.10092
Abstract
Donor-transmitted cancer (DTC) has major implications for the affected patient as well as other recipients of organs from the same donor. Unlike heterotopic transplant recipients, there may be limited treatment options for orthotopic transplant recipients with DTC. We systematically reviewed the evidence on DTC in orthotopic solid organ transplant recipients (SOTRs). We searched MEDLINE, EMBASE, PubMed, Scopus, and Web of Science in January 2020. We included cases where the outcome was reported and excluded donor-derived cancers. We assessed study quality using published checklists. Our domains of interest were presentation, time to diagnosis, cancer extent, management, and survival. There were 73 DTC cases in liver (n = 51), heart (n = 10), lung (n = 10) and multi-organ (n = 2) recipients from 58 publications. Study quality was variable. Median time to diagnosis was 8 months; 42% were widespread at diagnosis. Of 13 cases that underwent re-transplantation, three tumours recurred. Mortality was 75%; median survival 7 months. Survival was worst in transmitted melanoma and central nervous system tumours. The prognosis of DTC in orthotopic SOTRs is poor. Although re-transplantation offers the best chance of cure, some tumours still recur. Publication bias and clinical heterogeneity limit the available evidence. From our findings, we suggest refinements to clinical practice. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020165001, Prospero Registration Number: CRD42020165001.
Keywords
Health Archive, liver transplantation, cancer, heart transplantation, lung transplantation, donor-transmitted disease, deceased organ donors
Identifiers
10092
External DOI: https://doi.org/10.3389/ti.2021.10092
This record's DOI: https://doi.org/10.17863/CAM.81070
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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