Mechanisms of Choice in X-Chromosome Inactivation.
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Furlan, G., & Galupa, R. (2022). Mechanisms of Choice in X-Chromosome Inactivation.. Cells, 11 (3) https://doi.org/10.3390/cells11030535
Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate. This choice underlies phenotypical diversity in the composition of tissues and organs and in their response to the environment, and can determine whether an individual will be healthy or affected by an X-linked disease. Here, we review our current understanding of the process of choice during X-chromosome inactivation and its implications, focusing on the strategies evolved by different mammalian lineages and on the known and unknown molecular mechanisms and players involved.
X-chromosome inactivation, allelic choice, skewing, placentals, marsupials
European Molecular Biology Organization (EMBO ALTF 1132-2018)
Marie Skłodowska-Curie Actions (COFUND 664726)
External DOI: https://doi.org/10.3390/cells11030535
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333676