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dc.contributor.authorMcCoy, Airlie J
dc.contributor.authorSammito, Massimo D
dc.contributor.authorRead, Randy J
dc.date.accessioned2022-02-05T01:50:21Z
dc.date.available2022-02-05T01:50:21Z
dc.date.issued2022-01-01
dc.identifier.citationActa crystallographica. Section D, Structural biology, volume 78, issue Pt 1, page 1-13
dc.identifier.issn2059-7983
dc.identifier.other34981757
dc.identifier.otherPMC8725160
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333679
dc.description.abstractThe AlphaFold2 results in the 14th edition of Critical Assessment of Structure Prediction (CASP14) showed that accurate (low root-mean-square deviation) in silico models of protein structure domains are on the horizon, whether or not the protein is related to known structures through high-coverage sequence similarity. As highly accurate models become available, generated by harnessing the power of correlated mutations and deep learning, one of the aspects of structural biology to be impacted will be methods of phasing in crystallography. Here, the data from CASP14 are used to explore the prospects for changes in phasing methods, and in particular to explore the prospects for molecular-replacement phasing using in silico models.
dc.languageeng
dc.publisherInternational Union of Crystallography (IUCr)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101676043
dc.sourceessn: 2059-7983
dc.subjectMolecular replacement
dc.subjectProtein Structure Prediction
dc.subjectCrystallographic Phase Problem
dc.subjectAlphafold2
dc.titleImplications of AlphaFold2 for crystallographic phasing by molecular replacement.
dc.typeArticle
dc.date.updated2022-02-05T01:50:20Z
prism.publicationNameActa Crystallogr D Struct Biol
dc.identifier.doi10.17863/CAM.81098
dcterms.dateAccepted2021-11-13
rioxxterms.versionofrecord10.1107/S2059798321012122
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSammito, Massimo D [0000-0002-8346-9247]
dc.contributor.orcidRead, Randy J [0000-0001-8273-0047]
dc.identifier.eissn2059-7983
pubs.funder-project-idWellcome Trust (209407/Z/17/Z)
cam.issuedOnline2022-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International