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dc.contributor.authorAxelsson, Sebastian
dc.contributor.authorHorst, Nicole
dc.contributor.authorHoriguchi, Naotaka
dc.contributor.authorRoberts, Angela
dc.contributor.authorRobbins, Trevor
dc.date.accessioned2022-02-07T13:14:21Z
dc.date.available2022-02-07T13:14:21Z
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333709
dc.descriptionPreviously, studies using human neuroimaging and excitotoxic lesions in non-human primate have demonstrated an important role of ventrolateral prefrontal cortex (vlPFC) in higher order cognitive functions such as cognitive flexibility and the planning of behavioral sequences. In the present experiments, we tested effects on performance of temporary inactivation (using GABA receptor agonists) and dopamine D2 and 5-HT2A receptor blockade of vlPFC via local intracerebral infusions in the marmoset. We trained common marmosets to perform spatial self-ordered sequencing tasks in which one cohort of animals performed 2 and 3 response sequences on a continuously varying spatial array of response options on a touch-sensitive screen. Inactivation of vlPFC produced a marked disruption of accuracy of sequencing which also exhibited significant error perseveration. There were somewhat contrasting effects of D2 and 5HT2A receptor blockade, with the former producing error perseveration on incorrect trials, though not significantly impairing accuracy overall, and the latter significantly impairing accuracy but not error perseveration. A second cohort of marmosets were directly compared on performance of fixed versus variable spatial arrays. Inactivation of vlPFC again impaired self-ordered sequencing, but only with varying, and not fixed spatial arrays, the latter leading to the consistent use of fewer, preferred sequences. These findings add to evidence that vlPFC is implicated in goal-directed behavior that requires higher-order response heuristics that can be applied flexibly over different (variable), as compared to fixed stimulus exemplars. They also show that dopaminergic and serotonergic chemomodulation has distinctive effects on such performance. The behavioural data provided in this dataset support the publication "Flexible versus Fixed Spatial Self-Ordered Response Sequencing: Effects of Inactivation and Neurochemical Modulation of Ventrolateral Prefrontal Cortex".
dc.description.sponsorshipWellcome Trust 104631/Z/14/Z
dc.formatMicrosoft Excel
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectresponse sequence
dc.subjectfrontal cortex
dc.subjectmonoamine
dc.titleData from Axelsson et al 2021 "Flexible versus Fixed Spatial Self-Ordered Response Sequencing: Effects of inactivation and neurochemical modulation of ventrolateral prefrontal cortex" Journal of Neuroscience
dc.typeDataset
dc.publisher.departmentDepartment of Psychology
dc.date.updated2022-01-21T16:39:52Z
dc.identifier.doi10.17863/CAM.80292
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisorRobbins, Trevor William
dcterms.format.xlsx
dc.contributor.orcidHorst, Nicole [0000-0002-7145-8911]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
rioxxterms.typeOther
pubs.funder-project-idWellcome Trust (104631/Z/14/Z)
datacite.issupplementto.doi10.1523/JNEUROSCI.0227-21.2021
datacite.issupplementto.urlhttps://www.repository.cam.ac.uk/handle/1810/323296
cam.depositDate2022-01-21
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)