Research data supporting "Selective Role of the Putamen in Serial Reversal Learning in the Marmoset"
Axelsson, Sebastian Folke Amandus
MetadataShow full item record
Jackson, S., Horst, N., Axelsson, S. F. A., Horiguchi, N., Cockcroft, G., Robbins, T., & Roberts, A. (2022). Research data supporting "Selective Role of the Putamen in Serial Reversal Learning in the Marmoset" [Dataset]. https://doi.org/10.17863/CAM.31528
The data in this repository were collected from four marmosets performing a serial reversal task in a touchscreen apparatus. In each session, marmosets were presented with the same two visually distinct stimuli and had to determine, through trial and error, which stimulus to touch in order to earn a reward ("baseline discrimination phase"). Once criterion was reached in this initial phase, the stimulus-outcome contingencies reversed, such that responses to the previously unrewarded stimulus were now rewarded and vice versa (“reversal phase”). Trained marmosets were implanted with indwelling cannula in both the caudate nucleus and putamen. Varying doses of the GABA-A agonist muscimol were infused in experimental sessions to inactivate these areas separately in independent sessions. Performance following infusions of muscimol, as measured by errors committed (Figure 3) and trials completed, was compared both against control sessions with no infusions and sessions in which saline vehicle was infused into one of the target areas. Response latencies were also assessed and strategy usage was evaluated using a win-stay / lose-shift analysis. Performance across three timepoints spanning the length of the infusion experiment was analyzed to determine whether there were any effects of time in experiment, cannulation, or number of infusions. This repository contains data supporting the analysis and figures reported in the article "Selective Role of the Putamen in Serial Reversal Learning in the Marmoset".
Data were analyzed using the statistical computing language R version 3.3.1 with the Mac GUI R.app version 1.68. Both can be downloaded at no cost from http://www.cran.r-project.org/. Further details of the analysis methods used can be found in the Materials and Methods section of the main article.
marmoset, serial reversal learning, caudate nucleus, putamen, striatum
Publication Reference: https://doi.org/10.1093/cercor/bhy276https://www.repository.cam.ac.uk/handle/1810/286377
This work was supported by a Wellcome Trust Senior Investigator Award (104631/Z/14/Z to T.W.R.) and conducted within the University of Cambridge Behavioral and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council and the Wellcome Trust (MRCG1000183). Funding to pay the open access publication charges for this article was provided by the Wellcome Trust.
Wellcome Trust (104631/Z/14/Z)
This record's DOI: https://doi.org/10.17863/CAM.31528
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/