The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.
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Authors
Lafage-Pochitaloff, Marina
Juvin, Pierre-Yves
Bories, Pierre
Hébrard, Sylvie
Lagarde, Stéphanie
Barin, Carole
Bidet, Audrey
Boudjarane, John
Collonge-Rame, Marie-Agnès
Gervais, Carine
Lefebvre, Christine
Luquet, Isabelle
Nadal, Nathalie
Radford-Weiss, Isabelle
Ribourtout, Bénédicte
Richebourg, Steven
Terré, Christine
Tigaud, Isabelle
Penther, Dominique
Eclache, Virginie
Publication Date
2022-01-25Journal Title
Blood Adv
ISSN
2473-9529
Publisher
American Society of Hematology
Volume
6
Issue
2
Pages
386-398
Type
Article
This Version
VoR
Physical Medium
Print
Metadata
Show full item recordCitation
Lafage-Pochitaloff, M., Gerby, B., Baccini, V., Largeaud, L., Fregona, V., Prade, N., Juvin, P., et al. (2022). The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.. Blood Adv, 6 (2), 386-398. https://doi.org/10.1182/bloodadvances.2021005311
Abstract
Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis leading to peripheral cytopenias and in a substantial proportion of cases to acute myeloid leukemia. The deletion of the long arm of chromosome 11, del(11q), is a rare but recurrent clonal event in MDS. Here, we detail the largest series of 113 cases of MDS and myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) harboring a del(11q) analyzed at clinical, cytological, cytogenetic, and molecular levels. Female predominance, a survival prognosis similar to other MDS, a low monocyte count, and dysmegakaryopoiesis were the specific clinical and cytological features of del(11q) MDS. In most cases, del(11q) was isolated, primary and interstitial encompassing the 11q22-23 region containing ATM, KMT2A, and CBL genes. The common deleted region at 11q23.2 is centered on an intergenic region between CADM1 (also known as Tumor Suppressor in Lung Cancer 1) and NXPE2. CADM1 was expressed in all myeloid cells analyzed in contrast to NXPE2. At the functional level, the deletion of Cadm1 in murine Lineage-Sca1+Kit+ cells modifies the lymphoid-to-myeloid ratio in bone marrow, although not altering their multilineage hematopoietic reconstitution potential after syngenic transplantation. Together with the frequent simultaneous deletions of KMT2A, ATM, and CBL and mutations of ASXL1, SF3B1, and CBL, we show that CADM1 may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies.
Sponsorship
Medical Research Council (MC_PC_17230)
Identifiers
External DOI: https://doi.org/10.1182/bloodadvances.2021005311
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333750
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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