Left egocentric neglect in early subacute right-stroke patients is related to damage of the superior longitudinal fasciculus.
Authors
Nardo, Davide
Giulietti, Giovanni
Matano, Alessandro
Salsano, Ilenia
Briani, Chiara
Vadalà, Rita
Marzi, Claudia
De Luca, Maria
Caltagirone, Carlo
Santangelo, Valerio
Publication Date
2022-02Journal Title
Brain Imaging Behav
ISSN
1931-7557
Publisher
Springer Science and Business Media LLC
Volume
16
Issue
1
Pages
211-218
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Spanò, B., Nardo, D., Giulietti, G., Matano, A., Salsano, I., Briani, C., Vadalà, R., et al. (2022). Left egocentric neglect in early subacute right-stroke patients is related to damage of the superior longitudinal fasciculus.. Brain Imaging Behav, 16 (1), 211-218. https://doi.org/10.1007/s11682-021-00493-w
Abstract
A typical consequence of stroke in the right hemisphere is unilateral spatial neglect. Distinct forms of neglect have been described, such as space-based (egocentric) and object-based (allocentric) neglect. However, the relationship between these two forms of neglect is still far from being understood, as well as their neural substrates. Here, we further explore this issue by using voxel lesion symptoms mapping (VLSM) analyses on a large sample of early subacute right-stroke patients assessed with the Apples Cancellation Test. This is a sensitive test that simultaneously measures both egocentric and allocentric neglect. Behaviourally, we found no correlation between egocentric and allocentric performance, indicating independent mechanisms supporting the two forms of neglect. This was confirmed by the VLSM analysis that pointed out a link between a damage in the superior longitudinal fasciculus and left egocentric neglect. By contrast, no association was found between brain damage and left allocentric neglect. These results indicate a higher probability to observe egocentric neglect as a consequence of white matter damages in the superior longitudinal fasciculus, while allocentric neglect appears more "globally" related to the whole lesion map. Overall, these findings on early subacute right-stroke patients highlight the role played by white matter integrity in sustaining attention-related operations within an egocentric frame of reference.
Keywords
Original Research, Neglect, Egocentric, Allocentric, Neuroimaging, VLSM
Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_00005/1)
Identifiers
s11682-021-00493-w, 493
External DOI: https://doi.org/10.1007/s11682-021-00493-w
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333783
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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