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dc.contributor.authorHåkansson, Jonas
dc.contributor.authorJiang, Weili
dc.contributor.authorXue, Qian
dc.contributor.authorZheng, Xudong
dc.contributor.authorDing, Ming
dc.contributor.authorAgarwal, Anurag A
dc.contributor.authorElemans, Coen PH
dc.date.accessioned2022-02-09T13:22:56Z
dc.date.available2022-02-09T13:22:56Z
dc.date.issued2022-01-07
dc.identifier.issn1741-7007
dc.identifier.other34996429
dc.identifier.otherPMC8742360
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333792
dc.description.abstractBACKGROUND: Rodent ultrasonic vocalizations (USVs) are crucial to their social communication and a widely used translational tool for linking gene mutations to behavior. To maximize the causal interpretation of experimental treatments, we need to understand how neural control affects USV production. However, both the aerodynamics of USV production and its neural control remain poorly understood. RESULTS: Here, we test three intralaryngeal whistle mechanisms-the wall and alar edge impingement, and shallow cavity tone-by combining in vitro larynx physiology and individual-based 3D airway reconstructions with fluid dynamics simulations. Our results show that in the mouse and rat larynx, USVs are produced by a glottal jet impinging on the thyroid inner wall. Furthermore, we implemented an empirically based motor control model that predicts motor gesture trajectories of USV call types. CONCLUSIONS: Our results identify wall impingement as the aerodynamic mechanism of USV production in rats and mice. Furthermore, our empirically based motor control model shows that both neural and anatomical components contribute to USV production, which suggests that changes in strain specific USVs or USV changes in disease models can result from both altered motor programs and laryngeal geometry. Our work provides a quantitative neuromechanical framework to evaluate the contributions of brain and body in shaping USVs and a first step in linking descending motor control to USV production.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101190720
dc.sourceessn: 1741-7007
dc.subjectBioacoustics
dc.subjectAcoustic Communication
dc.subjectrodents
dc.subjectSpeech
dc.subjectVocal Production
dc.titleAerodynamics and motor control of ultrasonic vocalizations for social communication in mice and rats.
dc.typeArticle
dc.date.updated2022-02-09T13:22:55Z
prism.issueIdentifier1
prism.publicationNameBMC Biol
prism.volume20
dc.identifier.doi10.17863/CAM.81209
dcterms.dateAccepted2021-11-07
rioxxterms.versionofrecord10.1186/s12915-021-01185-z
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidHåkansson, Jonas [0000-0002-1247-5586]
dc.contributor.orcidJiang, Weili [0000-0002-7576-9653]
dc.contributor.orcidXue, Qian [0000-0002-8462-1271]
dc.contributor.orcidZheng, Xudong [0000-0001-5403-8862]
dc.contributor.orcidDing, Ming [0000-0002-6610-8079]
dc.contributor.orcidAgarwal, Anurag A [0000-0002-0332-2166]
dc.contributor.orcidElemans, Coen PH [0000-0001-6306-5715]
dc.identifier.eissn1741-7007
pubs.funder-project-idNatur og Univers, Det Frie Forskningsråd (7014-00270B)
pubs.funder-project-idNovo Nordisk Fonden (NNF20OC0063964)
cam.issuedOnline2022-01-07


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International