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dc.contributor.authorLautenschläger, Janin
dc.date.accessioned2022-02-09T13:23:25Z
dc.date.available2022-02-09T13:23:25Z
dc.date.issued2022-02
dc.date.submitted2021-11-09
dc.identifier.issn2046-2441
dc.identifier.otherrsob210334
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333800
dc.description.abstractFundamental discoveries have shaped our molecular understanding of presynaptic processes, such as neurotransmitter release, active zone organization and mechanisms of synaptic vesicle (SV) recycling. However, certain regulatory steps still remain incompletely understood. Protein liquid-liquid phase separation (LLPS) and its role in SV clustering and active zone regulation now introduce a new perception of how the presynapse and its different compartments are organized. This article highlights the newly emerging concept of LLPS at the synapse, providing a systematic overview on LLPS tendencies of over 500 presynaptic proteins, spotlighting individual proteins and discussing recent progress in the field. Newly discovered LLPS systems like ELKS/liprin-alpha and Eps15/FCho are put into context, and further LLPS candidate proteins, including epsin1, dynamin, synaptojanin, complexin and rabphilin-3A, are highlighted.
dc.languageen
dc.publisherThe Royal Society
dc.subjectReview
dc.subjectReview articles
dc.subjectsynapse
dc.subjectphase separation
dc.subjectactive zone
dc.subjectclathrin-mediated endocytosis
dc.subjectexocytosis
dc.subjectsynapsin
dc.titleProtein phase separation hotspots at the presynapse.
dc.typeArticle
dc.date.updated2022-02-09T13:23:24Z
prism.issueIdentifier2
prism.publicationNameOpen Biol
prism.volume12
dc.identifier.doi10.17863/CAM.81217
dcterms.dateAccepted2022-01-13
rioxxterms.versionofrecord10.1098/rsob.210334
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidLautenschläger, Janin [0000-0001-7788-7074]
dc.identifier.eissn2046-2441
pubs.funder-project-idRoyal Society (DHF/R1/201228)
cam.issuedOnline2022-02-09


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