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dc.contributor.authorYang, Zhirong
dc.contributor.authorEdwards, Duncan
dc.contributor.authorBurgess, Stephen
dc.contributor.authorBrayne, Carol
dc.contributor.authorMant, Jonathan
dc.date.accessioned2022-02-09T21:40:10Z
dc.date.available2022-02-09T21:40:10Z
dc.date.issued2022-04
dc.date.submitted2021-11-10
dc.identifier.issn1351-5101
dc.identifier.otherene15219
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333813
dc.description.abstractBACKGROUND AND PURPOSE: The roles of blood low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides in the development of post-stroke dementia remain uncertain. This study was to investigate their potential associations. METHODS: A retrospective cohort study was conducted using the Clinical Practice Research Datalink. Patients with first-ever stroke but no prior dementia were followed up for 10 years. Cox regression was used to examine the association of baseline LDL-C, HDL-C and triglycerides with post-stroke dementia. RESULTS: Amongst 63,959 stroke patients, 15,879 had complete baseline data and were included in our main analysis. 10.8% developed dementia during a median of 4.6 years of follow-up. The adjusted hazard ratio of dementia for LDL-C (per log mmol/l increase) was 1.29 (95% confidence interval [CI] 1.14-1.47), with a linear increasing trend (p trend <0.001). The counterpart for triglycerides was 0.79 (95% CI 0.69-0.89), with a linear decreasing trend (p trend <0.001). For HDL-C, there was no association with dementia (adjusted hazard ratio 0.89, 95% CI 0.74-1.08) or a linear trend (p trend = 0.22). CONCLUSIONS: Blood lipids may affect the risk of post-stroke dementia in different ways, with higher risk associated with LDL-C, lower risk associated with triglycerides, and no association with HDL-C.
dc.languageen
dc.publisherWiley
dc.subjectORIGINAL ARTICLE
dc.subjectORIGINAL ARTICLES
dc.subjectdementia
dc.subjectHDL cholesterol
dc.subjectLDL cholesterol
dc.subjectstroke
dc.subjecttriglycerides
dc.titleAssociation of major blood lipids with post-stroke dementia: A community-based cohort study.
dc.typeArticle
dc.date.updated2022-02-09T21:40:10Z
prism.publicationNameEur J Neurol
dc.identifier.doi10.17863/CAM.81233
dcterms.dateAccepted2021-12-10
rioxxterms.versionofrecord10.1111/ene.15219
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidYang, Zhirong [0000-0002-1562-0603]
dc.contributor.orcidEdwards, Duncan [0000-0003-1500-2108]
dc.contributor.orcidBurgess, Stephen [0000-0001-5365-8760]
dc.contributor.orcidBrayne, Carol [0000-0001-5307-663X]
dc.contributor.orcidMant, Jonathan [0000-0002-9531-0268]
dc.identifier.eissn1468-1331
pubs.funder-project-idWellcome Trust (204623/Z/16/Z)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
pubs.funder-project-idMedical Research Council (MC_UU_00002/7)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (CH/12/2/29428)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
cam.issuedOnline2022-01-26


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