Research data supporting "Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning"
Hervig, Mona El-Sayed
Robbins, Trevor W
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Hervig, M. E., Piilgaard, L., Bozic, T., Alsio, B., & Robbins, T. W. (2022). Research data supporting "Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning" [Dataset]. https://doi.org/10.17863/CAM.81230
Much evidence suggests that cognitive flexibility, which can be operationalized in reversal learning tasks, is mediated by cortico-striatal circuitries, with the orbitofrontal cortex (OFC) playing a prominent role. We investigated the effects on reversal learning of pharmacological overactivation of the lateral and medial orbitofrontal cortex (lOFC, mOFC) using a glutamate transporter 1 (GLT-1) inhibitor, dihydrokainate (DHK), which increases extracellular glutamate by blocking its reuptake. We also tested the impact of antagonism of the serotonin 2A receptor (5-HT2AR), which modulates glutamate action, in the mOFC and lOFC on the same task. Each .csv file corresponds to one experiment: reversal learning data from mOFC & lOFC, with rats receiving either the glutamate transporter 1 (GLT-1) inhibitor, dihydrokainate (DHK) or the antagonist of the serotonin 2A receptor (M-100,907).
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glutamate, orbitofrontal cortex, prefrontal cortex, reversal learning, serotonin
Publication Reference: https://doi.org/10.1037/pne0000221
This work was supported by a Wellcome Trust Senior Investigator Grant to TWR (104631/Z/14/Z) and a Lundbeck Foundation Research Fellowship to MEH (R182-2014–2810 and R210-2015–2982).
Wellcome Trust (104631/Z/14/Z)
This record's DOI: https://doi.org/10.17863/CAM.81230
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/