Expression Atlas update: gene and protein expression in multiple species.

Authors
Fexova, Silvie 
George, Nancy 
Manning, Jonathan R 

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Type
Article
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Abstract

The EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part, developmental stage, cell type) and under which conditions (disease, treatment, gender, etc) a gene or protein of interest is expressed. Expression Atlas brings together data from >4500 expression studies from >65 different species, across different conditions and tissues. It makes these data freely available in an easy to visualise form, after expert curation to accurately represent the intended experimental design, re-analysed via standardised pipelines that rely on open-source community developed tools. Each study's metadata are annotated using ontologies. The data are re-analyzed with the aim of reproducing the original conclusions of the underlying experiments. Expression Atlas is currently divided into Bulk Expression Atlas and Single Cell Expression Atlas. Expression Atlas contains data from differential studies (microarray and bulk RNA-Seq) and baseline studies (bulk RNA-Seq and proteomics), whereas Single Cell Expression Atlas is currently dedicated to Single Cell RNA-Sequencing (scRNA-Seq) studies. The resource has been in continuous development since 2009 and it is available at https://www.ebi.ac.uk/gxa.

Publication Date
2022-01-07
Online Publication Date
2021-11-24
Acceptance Date
2021-11-19
Keywords
Computational Biology, Databases, Genetic, Gene Expression Profiling, Humans, Proteins, Proteomics, RNA-Seq, Sequence Analysis, RNA, Single-Cell Analysis, Software
Journal Title
Nucleic Acids Res
Journal ISSN
0305-1048
1362-4962
Volume Title
50
Publisher
Oxford University Press (OUP)
Sponsorship
European Commission Horizon 2020 (H2020) Societal Challenges (874656)