Consensus nomenclature for dyneins and associated assembly factors.
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Authors
Omran, Heymut
Publication Date
2022-02-07Journal Title
J Cell Biol
ISSN
0021-9525
Publisher
Rockefeller University Press
Volume
221
Issue
2
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Braschi, B., Omran, H., Witman, G. B., Pazour, G. J., Pfister, K. K., Bruford, E. A., & King, S. M. (2022). Consensus nomenclature for dyneins and associated assembly factors.. J Cell Biol, 221 (2) https://doi.org/10.1083/jcb.202109014
Abstract
Dyneins are highly complex, multicomponent, microtubule-based molecular motors. These enzymes are responsible for numerous motile behaviors in cytoplasm, mediate retrograde intraflagellar transport (IFT), and power ciliary and flagellar motility. Variants in multiple genes encoding dyneins, outer dynein arm (ODA) docking complex subunits, and cytoplasmic factors involved in axonemal dynein preassembly (DNAAFs) are associated with human ciliopathies and are of clinical interest. Therefore, clear communication within this field is particularly important. Standardizing gene nomenclature, and basing it on orthology where possible, facilitates discussion and genetic comparison across species. Here, we discuss how the human gene nomenclature for dyneins, ODA docking complex subunits, and DNAAFs has been updated to be more functionally informative and consistent with that of the unicellular green alga Chlamydomonas reinhardtii, a key model organism for studying dyneins and ciliary function. We also detail additional nomenclature updates for vertebrate-specific genes that encode dynein chains and other proteins involved in dynein complex assembly.
Sponsorship
Wellcome Trust (208349/Z/17/Z)
NIH HHS (R35-GM140631)
NHGRI NIH HHS (U24 HG003345, U24HG003345)
National Human Genome Research Institute (U24HG003345)
NIGMS NIH HHS (R35 GM140631)
National Institutes of Health (R35-GM140631)
Identifiers
35006274, PMC8754002
External DOI: https://doi.org/10.1083/jcb.202109014
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333886
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