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dc.contributor.authorMba, CM
dc.contributor.authorKoulman, A
dc.contributor.authorForouhi, NG
dc.contributor.authorImamura, F
dc.contributor.authorAssah, F
dc.contributor.authorMbanya, JC
dc.contributor.authorWareham, NJ
dc.date.accessioned2022-02-11T02:33:09Z
dc.date.available2022-02-11T02:33:09Z
dc.date.issued2021-12-30
dc.identifier.issn2072-6643
dc.identifier.other35011051
dc.identifier.otherPMC8747568
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333887
dc.description.abstractA low intake of fruit and vegetables and a high intake of meat are associated with higher cardiometabolic disease risk; however much prior research has relied on subjective methods for dietary assessment and focused on Western populations. We aimed to investigate the association of blood folate as an objective marker of fruit and vegetable intake and holotranscobalamin (holoTC) as a marker of animal-sourced food intake with cardiometabolic risk factors. We con-ducted a population-based cross-sectional study on 578 adults (mean ± SD age = 38.2 ± 8.6 years; 64% women). The primary outcome was a continuous metabolic syndrome score. The median serum folate was 12.9 (IQR: 8.6–20.5) nmol/L and the mean holoTC was 75 (SD: 34.3) pmol/L. Rural residents demonstrated higher serum folate concentrations (15.9 (9.8–25.9) nmol/L) than urban residents (11.3 (7.9–15.8) nmol/L), but lower holoTC concentrations (rural: 69.8 (32.9) pmol/L; urban: 79.8 (34.9)) pmol/L, p < 0.001 for both comparisons. There was an inverse association between serum folate and metabolic syndrome score by −0.20 in the z-score (95% CI, −0.38 to −0.02) per 10.8 (1 SD) of folate) in a model adjusted for socio-demographic factors, smoking status, alcohol intake, BMI, and physical activity. HoloTC was positively associated with the metabolic syndrome score in unadjusted analysis (0.33 (95% CI, 0.10 to 0.56)) but became non-significant (0.17 (−0.05 to 0.39)) after adjusting for socio-demographic and behavioural characteristics. In conclusion, serum folate and holoTC were associated with the metabolic syndrome score in opposite directions. The positive association between serum holoTC and the metabolic syndrome score was partly dependent on sociodemographic characteristics. These findings suggest that, based on these biomarkers reflecting dietary intakes, public health approaches promoting a higher intake of fruit and vegetables may lower cardiometabolic risk factors in this population.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101521595
dc.sourceessn: 2072-6643
dc.subjectSerum Folate
dc.subjectCardiometabolic Risk Factors
dc.subjectHolotranscobalamin
dc.subjectHumans
dc.subjectFruit
dc.subjectVegetables
dc.subjectTranscobalamins
dc.subjectFolic Acid
dc.subjectCross-Sectional Studies
dc.subjectEating
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectRural Population
dc.subjectUrban Population
dc.subjectHealth Promotion
dc.subjectCameroon
dc.subjectFemale
dc.subjectMale
dc.subjectBiomarkers
dc.subjectMetabolic Syndrome
dc.subjectAnimal Proteins, Dietary
dc.titleAssociations of serum folate and holotranscobalamin with cardiometabolic risk factors in rural and urban cameroon
dc.typeArticle
dc.date.updated2022-02-11T02:33:09Z
prism.issueIdentifier1
prism.publicationNameNutrients
prism.volume14
dc.identifier.doi10.17863/CAM.81303
dcterms.dateAccepted2021-12-27
rioxxterms.versionofrecord10.3390/nu14010178
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn2072-6643
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idMRC (MC_UU_00006/3)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NIHR202397)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M027252/2)
cam.issuedOnline2021-12-30


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International