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dc.contributor.authorGog, Julia
dc.contributor.authorHill, Edward M
dc.contributor.authorDanon, Leon
dc.contributor.authorThompson, Robin N
dc.date.accessioned2022-02-11T13:40:28Z
dc.date.available2022-02-11T13:40:28Z
dc.date.issued2021-07
dc.date.submitted2021-03-31
dc.identifier.issn2054-5703
dc.identifier.otherrsos210530
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333912
dc.description.abstractAs a countermeasure to the SARS-CoV-2 pandemic, there has been swift development and clinical trial assessment of candidate vaccines, with subsequent deployment as part of mass vaccination campaigns. However, the SARS-CoV-2 virus has demonstrated the ability to mutate and develop variants, which can modify epidemiological properties and potentially also the effectiveness of vaccines. The widespread deployment of highly effective vaccines may rapidly exert selection pressure on the SARS-CoV-2 virus directed towards mutations that escape the vaccine-induced immune response. This is particularly concerning while infection is widespread. By developing and analysing a mathematical model of two population groupings with differing vulnerability and contact rates, we explore the impact of the deployment of vaccines among the population on the reproduction ratio, cases, disease abundance and vaccine escape pressure. The results from this model illustrate two insights: (i) vaccination aimed at reducing prevalence could be more effective at reducing disease than directly vaccinating the vulnerable; (ii) the highest risk for vaccine escape can occur at intermediate levels of vaccination. This work demonstrates a key principle: the careful targeting of vaccines towards particular population groups could reduce disease as much as possible while limiting the risk of vaccine escape.
dc.languageen
dc.publisherThe Royal Society
dc.subjectScience, society and policy
dc.subjectResearch articles
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectvaccine
dc.subjectvaccine escape
dc.subjectheterogeneous population
dc.subjectpolicy
dc.titleVaccine escape in a heterogeneous population: insights for SARS-CoV-2 from a simple model.
dc.typeArticle
dc.date.updated2022-02-11T13:40:28Z
prism.issueIdentifier7
prism.publicationNameR Soc Open Sci
prism.volume8
dc.identifier.doi10.17863/CAM.81328
dcterms.dateAccepted2021-07-01
rioxxterms.versionofrecord10.1098/rsos.210530
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGog, Julia [0000-0003-1240-7214]
dc.contributor.orcidHill, Edward M [0000-0002-2992-2004]
dc.contributor.orcidDanon, Leon [0000-0002-7076-1871]
dc.contributor.orcidThompson, Robin N [0000-0001-8545-5212]
dc.identifier.eissn2054-5703
pubs.funder-project-idMRC (via University of Warwick) (MR/V038613/1)
cam.issuedOnline2021-07-14


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