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dc.contributor.authorApšvalka, Dace
dc.contributor.authorFerreira, Catarina S
dc.contributor.authorSchmitz, Taylor W
dc.contributor.authorRowe, James
dc.contributor.authorAnderson, Mike
dc.date.accessioned2022-02-14T02:02:00Z
dc.date.available2022-02-14T02:02:00Z
dc.date.issued2022-01-12
dc.identifier.issn2041-1723
dc.identifier.otherPMC8755760
dc.identifier.other35022447
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333979
dc.description.abstractOver the last two decades, inhibitory control has featured prominently in accounts of how humans and other organisms regulate their behaviour and thought. Previous work on how the brain stops actions and thoughts, however, has emphasised distinct prefrontal regions supporting these functions, suggesting domain-specific mechanisms. Here we show that stopping actions and thoughts recruits common regions in the right dorsolateral and ventrolateral prefrontal cortex to suppress diverse content, via dynamic targeting. Within each region, classifiers trained to distinguish action-stopping from action-execution also identify when people are suppressing their thoughts (and vice versa). Effective connectivity analysis reveals that both prefrontal regions contribute to action and thought stopping by targeting the motor cortex or the hippocampus, depending on the goal, to suppress their task-specific activity. These findings support the existence of a domain-general system that underlies inhibitory control and establish Dynamic Targeting as a mechanism enabling this ability.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101528555
dc.sourceessn: 2041-1723
dc.titleDynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex.
dc.typeArticle
dc.date.updated2022-02-14T02:01:59Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume13
dc.identifier.doi10.17863/CAM.81396
dcterms.dateAccepted2021-12-21
rioxxterms.versionofrecord10.1038/s41467-021-27926-w
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidApšvalka, Dace [0000-0002-5618-8108]
dc.contributor.orcidFerreira, Catarina S [0000-0003-3858-8113]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.contributor.orcidAnderson, Mike [0000-0001-9505-9299]
dc.identifier.eissn2041-1723
pubs.funder-project-idMedical Research Council (MC_UU_00005/1)
pubs.funder-project-idMedical Research Council (MC_UU_00005/12)
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idMedical Research Council (MC_UU_00005/14)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
cam.issuedOnline2022-01-12


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International