Insights from structural studies of the cardiovirus 2A protein.
Portland Press Ltd.
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Caliskan, N., & Hill, C. H. (2022). Insights from structural studies of the cardiovirus 2A protein.. Biosci Rep, 42 (1) https://doi.org/10.1042/BSR20210406
Cardioviruses are single-stranded RNA viruses of the family Picornaviridae. In addition to being the first example of internal ribosome entry site (IRES) utilization, cardioviruses also employ a series of alternative translation strategies, such as Stop-Go translation and programmed ribosome frameshifting. Here, we focus on cardiovirus 2A protein, which is not only a primary virulence factor, but also exerts crucial regulatory functions during translation, including activation of viral ribosome frameshifting and inhibition of host cap-dependent translation. Only recently, biochemical and structural studies have allowed us to close the gaps in our knowledge of how cardiovirus 2A is able to act in diverse translation-related processes as a novel RNA-binding protein. This review will summarize these findings, which ultimately may lead to the discovery of other RNA-mediated gene expression strategies across a broad range of RNA viruses.
Translation, Virology, RNA-binding proteins, Cardiovirus, Viral Proteins, Internal Ribosome Entry Sites
Wellcome Trust (221818/Z/20/Z)
European Research Council (948636)
External DOI: https://doi.org/10.1042/BSR20210406
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333982
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/