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dc.contributor.authorFabrini, Giacomo
dc.contributor.authorMinard, Aisling
dc.contributor.authorBrady, Ryan A
dc.contributor.authorDi Antonio, Marco
dc.contributor.authorDi Michele, Lorenzo
dc.date.accessioned2022-02-14T02:02:13Z
dc.date.available2022-02-14T02:02:13Z
dc.date.issued2022-01-26
dc.identifier.issn1530-6984
dc.identifier.otherPMC8796241
dc.identifier.other35026112
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333983
dc.descriptionFunder: Imperial College London
dc.description.abstractThanks to its biocompatibility, versatility, and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering, and drug delivery. Of particular importance for in vivo applications is the possibility of making such nanomaterials responsive to physiological stimuli. Here, we demonstrate how combining noncanonical DNA G-quadruplex (G4) structures with amphiphilic DNA constructs yields nanostructures, which we termed "Quad-Stars", capable of assembling into responsive hydrogel particles via a straightforward, enzyme-free, one-pot reaction. The embedded G4 structures allow one to trigger and control the assembly/disassembly in a reversible fashion by adding or removing K+ ions. Furthermore, the hydrogel aggregates can be photo-disassembled upon near-UV irradiation in the presence of a porphyrin photosensitizer. The combined reversibility of assembly, responsiveness, and cargo-loading capabilities of the hydrophobic moieties make Quad-Stars a promising candidate for biosensors and responsive drug delivery carriers.
dc.languageeng
dc.publisherAmerican Chemical Society (ACS)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcenlmid: 101088070
dc.sourceessn: 1530-6992
dc.subjectSelf-assembly
dc.subjectDna Nanotechnology
dc.subjectG-quadruplexes
dc.subjectStimuli-responsive Hydrogels
dc.subjectAmphiphilic Dna
dc.titleCation-Responsive and Photocleavable Hydrogels from Noncanonical Amphiphilic DNA Nanostructures.
dc.typeArticle
dc.date.updated2022-02-14T02:02:12Z
prism.endingPage611
prism.issueIdentifier2
prism.publicationNameNano Lett
prism.startingPage602
prism.volume22
dc.identifier.doi10.17863/CAM.81400
rioxxterms.versionofrecord10.1021/acs.nanolett.1c03314
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.contributor.orcidBrady, Ryan A [0000-0002-0408-3224]
dc.contributor.orcidDi Antonio, Marco [0000-0002-7321-1867]
dc.contributor.orcidDi Michele, Lorenzo [0000-0002-1458-9747]
dc.identifier.eissn1530-6992
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/R011605/1)
pubs.funder-project-idRoyal Society (UF160152)
pubs.funder-project-idEuropean Research Council (851667 NANOCELL, 851667)
cam.issuedOnline2022-01-13


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International