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dc.contributor.authorMilde, Stefan
dc.contributor.authorBrown, Guy
dc.date.accessioned2022-02-16T00:30:29Z
dc.date.available2022-02-16T00:30:29Z
dc.date.issued2022-02-19
dc.identifier.issn1661-6596
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334063
dc.description.abstractAfter stroke, there is a delayed neuronal loss in brain areas surrounding the infarct, which may in part be mediated by microglial phagocytosis of stressed neurons. Microglial phagocytosis of stressed or damaged neurons can be mediated by UDP released from stressed neurons activating the P2Y6 receptor on microglia, inducing microglial phagocytosis of such neurons. We show evidence here from a small trial that the knockout of the P2Y6 receptor, required for microglial phagocytosis of neurons, prevents the delayed neuronal loss after transient, focal brain ischemia induced by endothelin-1 injection in mice. Wild-type mice had neuronal loss and neuronal nuclear material within microglia in peri-infarct areas. P2Y6 receptor knockout mice had no significant neuronal loss in peri-infarct brain areas seven days after brain ischemia. Thus, delayed neuronal loss after stroke may in part be mediated by microglial phagocytosis of stressed neurons, and the P2Y6 receptor is a potential treatment target to prevent peri-infarct neuronal loss.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleKnockout of the P2Y6 Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain.
dc.typeArticle
dc.publisher.departmentDepartment of Biochemistry
dc.date.updated2022-02-15T10:25:11Z
prism.publicationNameInt J Mol Sci
dc.identifier.doi10.17863/CAM.81474
dcterms.dateAccepted2022-02-15
rioxxterms.versionofrecord10.3390/ijms23042304
rioxxterms.versionAM
dc.contributor.orcidBrown, Guy [0000-0002-3610-1730]
dc.identifier.eissn1422-0067
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/L010593/1)
cam.orpheus.successWed Mar 23 10:26:33 GMT 2022 - Embargo updated*
cam.orpheus.counter1
cam.depositDate2022-02-15
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-02-19


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International