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dc.contributor.authorAlmeida, Miguel Vasconcelos
dc.contributor.authorVernaz, Grégoire
dc.contributor.authorPutman, Audrey LK
dc.contributor.authorMiska, Eric A
dc.date.accessioned2022-02-16T00:30:53Z
dc.date.available2022-02-16T00:30:53Z
dc.date.issued2022-06
dc.identifier.issn0168-9525
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334069
dc.description.abstractTransposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes known to date. Because their expression and mobility can lead to genomic instability, several pathways have evolved to control TEs. Nevertheless, TEs represent an important source of genomic novelty and are often co-opted for novel functions that are relevant for phenotypic divergence and adaptation. Here, we review how animals, in particular vertebrates, mitigate TE mobility and expression, alongside known examples of TE domestication. We argue that the next frontier is to understand the determinants and dynamics of TE domestication: how they shift from 'non-self' targets of epigenetic silencing to 'self' genetic elements. New technologies enable avenues of research that may close the gap between epigenetic silencing and domestication of TEs.
dc.description.sponsorshipThis work was supported by the following grants to E.A.M.: Wellcome Trust Senior Investigator Award (219475/Z/19/Z) and CRUK awards (C13474 and A27826). M.V.A. is funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101027241. G.V. thanks Wolfson College at the University of Cambridge, and the Genetics Society, London for financial support. A.L.K.P. is grateful to the Cambridge Commonwealth, European & International Trust for financial support. Finally, the authors also acknowledge core funding to the Gurdon Institute from Wellcome (092096/Z/10/Z, 203144/Z/16/Z) and CRUK (C6946/A24843). For Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTE domestication
dc.subjectepigenetic silencing
dc.subjectgenome evolution
dc.subjecttransposable elements (TEs)
dc.subjectvertebrates
dc.subjectAnimals
dc.subjectDNA Transposable Elements
dc.subjectDomestication
dc.subjectEpigenesis, Genetic
dc.subjectEukaryota
dc.subjectEvolution, Molecular
dc.subjectVertebrates
dc.titleTaming transposable elements in vertebrates: from epigenetic silencing to domestication.
dc.typeArticle
dc.publisher.departmentWellcome Trust/Cancer Research Uk Gurdon Institute
dc.date.updated2022-02-15T13:09:10Z
prism.publicationNameTrends Genet
dc.identifier.doi10.17863/CAM.81480
dcterms.dateAccepted2022-02-15
rioxxterms.versionofrecord10.1016/j.tig.2022.02.009
rioxxterms.versionAM
dc.contributor.orcidMiska, Eric [0000-0002-4450-576X]
dc.identifier.eissn1362-4555
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (219475/Z/19/Z)
pubs.funder-project-idCancer Research UK (A27826)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (101027241)
pubs.funder-project-idWellcome Trust (203144/Z/16/Z)
pubs.funder-project-idCancer Research UK (C6946/A24843)
cam.issuedOnline2022-03-17
cam.orpheus.successTue Apr 12 08:22:37 BST 2022 - Embargo updated
cam.orpheus.counter3
cam.depositDate2022-02-15
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-03-17


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International