Pulse consumption improves indices of glycemic control in adults with and without type 2 diabetes: a systematic review and meta-analysis of acute and long-term randomized controlled trials.
Authors
Publication Date
2022-03Journal Title
Eur J Nutr
ISSN
1436-6207
Publisher
Springer Science and Business Media LLC
Volume
61
Issue
2
Pages
809-824
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Hafiz, M. S., Campbell, M. D., O'Mahoney, L. L., Holmes, M., Orfila, C., & Boesch, C. (2022). Pulse consumption improves indices of glycemic control in adults with and without type 2 diabetes: a systematic review and meta-analysis of acute and long-term randomized controlled trials.. Eur J Nutr, 61 (2), 809-824. https://doi.org/10.1007/s00394-021-02685-y
Description
Funder: University of Leeds
Abstract
PURPOSE: Findings from randomized controlled trials (RCTs) evaluating the effect of pulse intake on glycemic control are inconsistent and conclusive evidence is lacking. The aim of this study was to systematically review the impact of pulse consumption on post-prandial and long-term glycemic control in adults with and without type 2 diabetes (T2D). METHODS: Databases were searched for RCTs, reporting outcomes of post-prandial and long-term interventions with different pulse types on parameters of glycemic control in normoglycemic and T2D adults. Effect size (ES) was calculated using random effect model and meta-regression was conducted to assess the impact of various moderator variables such as pulse type, form, dose, and study duration on ES. RESULTS: From 3334 RCTs identified, 65 studies were eligible for inclusion involving 2102 individuals. In acute RCTs, pulse intake significantly reduced peak post-prandial glucose concentration in participants with T2D (ES - 2.90; 95%CI - 4.60, - 1.21; p ≤ 0.001; I2 = 93%) and without T2D (ES - 1.38; 95%CI - 1.78, - 0.99; p ≤ 0.001; I2 = 86%). Incorporating pulse consumption into long-term eating patterns significantly attenuated fasting glucose in normoglycemic adults (ES - 0.06; 95%CI - 0.12, 0.00; p ≤ 0.05; I2 = 30%). Whereas, in T2D participants, pulse intake significantly lowered fasting glucose (ES - 0.54; 95%CI - 0.83, - 0.24; p ≤ 0.001; I2 = 78%), glycated hemoglobin A1c (HbA1c) (ES - 0.17; 95%CI - 0.33, 0.00; p ≤ 0.05; I2 = 78) and homeostatic model assessment of insulin resistance (HOMA-IR) (ES - 0.47; 95%CI - 1.25, - 0.31; p ≤ 0.05; I2 = 79%). CONCLUSION: Pulse consumption significantly reduced acute post-prandial glucose concentration > 1 mmol/L in normoglycemic adults and > 2.5 mmol/L in those with T2D, and improved a range of long-term glycemic control parameters in adults with and without T2D. PROSPERO REGISTRY NUMBER: (CRD42019162322).
Keywords
Original Contribution, CRD42019162322, CRD, Pulses, Glucose, Diabetes, Postprandial glycemia, Systematic review, Meta-analysis
Sponsorship
King Abdulaziz University (PhD scholarship)
Identifiers
s00394-021-02685-y, 2685
External DOI: https://doi.org/10.1007/s00394-021-02685-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334155
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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