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dc.contributor.authorBazydlo, Austin M
dc.contributor.authorZammit, Matthew D
dc.contributor.authorWu, Minjie
dc.contributor.authorLao, Patrick J
dc.contributor.authorDean, Douglas C
dc.contributor.authorJohnson, Sterling C
dc.contributor.authorTudorascu, Dana L
dc.contributor.authorCohen, Ann
dc.contributor.authorCody, Karly A
dc.contributor.authorAnces, Beau
dc.contributor.authorLaymon, Charles M
dc.contributor.authorKlunk, William E
dc.contributor.authorZaman, Shahid
dc.contributor.authorHanden, Benjamin L
dc.contributor.authorHartley, Sigan L
dc.contributor.authorAlexander, Andrew L
dc.contributor.authorChristian, Bradley T
dc.date.accessioned2022-02-18T00:34:05Z
dc.date.available2022-02-18T00:34:05Z
dc.date.issued2022
dc.identifier.issn2213-1582
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334183
dc.description.abstractINTRODUCTION: Individuals with Down syndrome (DS) are at an increased risk of developing Alzheimer's Disease (AD). One of the early underlying mechanisms in AD pathology is the accumulation of amyloid protein plaques, which are deposited in extracellular gray matter and signify the first stage in the cascade of neurodegenerative events. AD-related neurodegeneration is also evidenced as microstructural changes in white matter. In this work, we explored the correlation of white matter microstructure with amyloid load to assess amyloid-related neurodegeneration in a cohort of adults with DS. METHODS: In this study of 96 adults with DS, the relation of white matter microstructure using diffusion tensor imaging (DTI) and amyloid plaque burden using [11C]PiB PET were examined. The amyloid load (AβL) derived from [11C]PiB was used as a global measure of amyloid burden. AβL and DTI measures were compared using tract-based spatial statistics (TBSS) and corrected for imaging site and chronological age. RESULTS: TBSS of the DTI maps showed widespread age-by-amyloid interaction with both fractional anisotropy (FA) and mean diffusivity (MD). Further, diffuse negative association of FA and positive association of MD with amyloid were observed. DISCUSSION: These findings are consistent with the white matter microstructural changes associated with AD disease progression in late onset AD in non-DS populations.
dc.format.mediumPrint-Electronic
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAlzheimer’s Disease
dc.subjectAmyloid-β
dc.subjectDTI
dc.subjectDown syndrome
dc.subjectPET
dc.titleWhite matter microstructure associations to amyloid burden in adults with Down syndrome.
dc.typeArticle
dc.publisher.departmentDepartment of Psychiatry
dc.date.updated2022-02-17T14:46:33Z
prism.number102908
prism.publicationDate2021
prism.publicationNameNeuroimage Clin
prism.startingPage102908
prism.volume33
dc.identifier.doi10.17863/CAM.81594
dcterms.dateAccepted2021-12-03
rioxxterms.versionofrecord10.1016/j.nicl.2021.102908
rioxxterms.versionVoR
dc.contributor.orcidZaman, Shahid [0000-0003-1639-6014]
dc.identifier.eissn2213-1582
rioxxterms.typeJournal Article/Review
pubs.funder-project-idNational Institutes of Health (NIH) (via University of Pittsburgh) (AWD00002130 (134286-8)/134286)
cam.issuedOnline2021-12-10
cam.depositDate2022-02-17
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International