Reward Processing in Children With Psychotic-Like Experiences.
View / Open Files
Authors
Publication Date
2022-01Journal Title
Schizophr Bull Open
ISSN
2632-7899
Publisher
Oxford University Press (OUP)
Volume
3
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Harju-Seppänen, J., Irizar, H., Bramon, E., Blakemore, S., Mason, L., & Bell, V. (2022). Reward Processing in Children With Psychotic-Like Experiences.. Schizophr Bull Open, 3 (1) https://doi.org/10.1093/schizbullopen/sgab054
Abstract
Alterations to striatal reward pathways have been identified in individuals with psychosis. They are hypothesized to be a key mechanism that generate psychotic symptoms through the production of aberrant attribution of motivational salience and are proposed to result from accumulated childhood adversity and genetic risk, making the striatal system hyper-responsive to stress. However, few studies have examined whether children with psychotic-like experiences (PLEs) also exhibit these alterations, limiting our understanding of how differences in reward processing relate to hallucinations and delusional ideation in childhood. Consequently, we examined whether PLEs and PLE-related distress were associated with reward-related activation in the nucleus accumbens (NAcc). The sample consisted of children (N = 6718) from the Adolescent Brain Cognitive Development (ABCD) study aged 9-10 years who had participated in the Monetary Incentive Delay (MID) task in functional MRI. We used robust mixed-effects linear regression models to investigate the relationship between PLEs and NAcc activation during the reward anticipation and reward outcome stages of the MID task. Analyses were adjusted for gender, household income, ethnicity, depressive symptoms, movement in the scanner, pubertal development, scanner ID, subject and family ID. There was no reliable association between PLEs and alterations to anticipation- or outcome-related striatal reward processing. We discuss the implications for developmental models of psychosis and suggest a developmental delay model of how PLEs may arise at this stage of development.
Keywords
fMRI, Childhood, Psychotic-like Experiences
Sponsorship
National Institute for Health Research (NIHR) (NIHR200756)
Identifiers
PMC8756103, 35036918
External DOI: https://doi.org/10.1093/schizbullopen/sgab054
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334188
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.