Show simple item record

dc.contributor.authorHarju-Seppänen, Jasmine
dc.contributor.authorIrizar, Haritz
dc.contributor.authorBramon, Elvira
dc.contributor.authorBlakemore, Sarah-Jayne
dc.contributor.authorMason, Liam
dc.contributor.authorBell, Vaughan
dc.date.accessioned2022-02-18T02:03:12Z
dc.date.available2022-02-18T02:03:12Z
dc.date.issued2022-01
dc.identifier.issn2632-7899
dc.identifier.otherPMC8756103
dc.identifier.other35036918
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334188
dc.description.abstractAlterations to striatal reward pathways have been identified in individuals with psychosis. They are hypothesized to be a key mechanism that generate psychotic symptoms through the production of aberrant attribution of motivational salience and are proposed to result from accumulated childhood adversity and genetic risk, making the striatal system hyper-responsive to stress. However, few studies have examined whether children with psychotic-like experiences (PLEs) also exhibit these alterations, limiting our understanding of how differences in reward processing relate to hallucinations and delusional ideation in childhood. Consequently, we examined whether PLEs and PLE-related distress were associated with reward-related activation in the nucleus accumbens (NAcc). The sample consisted of children (N = 6718) from the Adolescent Brain Cognitive Development (ABCD) study aged 9-10 years who had participated in the Monetary Incentive Delay (MID) task in functional MRI. We used robust mixed-effects linear regression models to investigate the relationship between PLEs and NAcc activation during the reward anticipation and reward outcome stages of the MID task. Analyses were adjusted for gender, household income, ethnicity, depressive symptoms, movement in the scanner, pubertal development, scanner ID, subject and family ID. There was no reliable association between PLEs and alterations to anticipation- or outcome-related striatal reward processing. We discuss the implications for developmental models of psychosis and suggest a developmental delay model of how PLEs may arise at this stage of development.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourcenlmid: 101770329
dc.sourceessn: 2632-7899
dc.subjectfMRI
dc.subjectChildhood
dc.subjectPsychotic-like Experiences
dc.titleReward Processing in Children With Psychotic-Like Experiences.
dc.typeArticle
dc.date.updated2022-02-18T02:03:11Z
prism.issueIdentifier1
prism.publicationNameSchizophr Bull Open
prism.volume3
dc.identifier.doi10.17863/CAM.81599
rioxxterms.versionofrecord10.1093/schizbullopen/sgab054
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.contributor.orcidHarju-Seppänen, Jasmine [0000-0002-9027-2119]
dc.contributor.orcidIrizar, Haritz [0000-0003-3594-9040]
dc.contributor.orcidBramon, Elvira [0000-0003-1369-5983]
dc.contributor.orcidBlakemore, Sarah-Jayne [0000-0002-1690-2805]
dc.contributor.orcidMason, Liam [0000-0003-3957-1436]
dc.contributor.orcidBell, Vaughan [0000-0001-8616-4847]
dc.identifier.eissn2632-7899
pubs.funder-project-idNational Institute for Health Research (NIHR) (NIHR200756)
cam.issuedOnline2021-12-04


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International