KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.
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Authors
Iouranova, Alexandra
Grun, Delphine
Rossy, Tamara
Duc, Julien
Coudray, Alexandre
Imbeault, Michael
de Tribolet-Hardy, Jonas
Turelli, Priscilla
Persat, Alexandre
Publication Date
2022-01-18Journal Title
Mob DNA
ISSN
1759-8753
Publisher
Springer Science and Business Media LLC
Volume
13
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Iouranova, A., Grun, D., Rossy, T., Duc, J., Coudray, A., Imbeault, M., de Tribolet-Hardy, J., et al. (2022). KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences.. Mob DNA, 13 (1) https://doi.org/10.1186/s13100-021-00260-0
Abstract
BACKGROUND: Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to gene regulation in early human development and germ cells. RESULTS: Here, after studying genes driven by the long terminal repeat (LTR) of endogenous retroviruses, we identify the ape-restricted ZNF676 as the sequence-specific repressor of a subset of contemporary LTR12 integrants responsible for a large fraction of transpochimeric gene transcripts (TcGTs) generated during human early embryogenesis. We go on to reveal that the binding of this KZFP correlates with the epigenetic marking of these TEeRS in the germline, and is crucial to the control of genes involved in ciliogenesis/flagellogenesis, a biological process that dates back to the last common ancestor of eukaryotes. CONCLUSION: These results illustrate how KZFPs and their TE targets contribute to the evolutionary turnover of transcription networks and participate in the transgenerational inheritance of epigenetic traits.
Sponsorship
European Research Council (268721,694658)
Identifiers
PMC8767690, 35042549
External DOI: https://doi.org/10.1186/s13100-021-00260-0
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334242
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