Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits.
Authors
Mason, Luke
STAARS Team
Publication Date
2022-09Journal Title
J Child Psychol Psychiatry
ISSN
0021-9630
Publisher
Wiley
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Begum-Ali, J., Goodwin, A., Mason, L., Pasco, G., Charman, T., Johnson, M. H., Jones, E. J., & et al. (2022). Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits.. J Child Psychol Psychiatry https://doi.org/10.1111/jcpp.13563
Description
Funder: European Federation of Pharmaceutical Industries and Associations; Id: http://dx.doi.org/10.13039/100013322
Funder: Autistica; Id: http://dx.doi.org/10.13039/100011706
Funder: Simons Foundation Autism Research Initiative; Id: http://dx.doi.org/10.13039/100014370
Funder: Autism Speaks; Id: http://dx.doi.org/10.13039/100000073
Abstract
BACKGROUND: Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prospective studies of infants with an elevated likelihood of developing ADHD. METHODS: We used a prospective design to examine an oscillatory electroencephalography profile that has been widely studied in both children and adults with ADHD - the balance between lower and higher frequencies operationalised as the theta-beta ratio (TBR). In the present study, we examined TBR in 136 10-month-old infants (72 male and 64 female) with/without an elevated likelihood of developing ADHD and/or a comparison disorder (Autism Spectrum Disorder; ASD). RESULTS: Infants with a first-degree relative with ADHD demonstrated lower TBR than infants without a first-degree relative with ADHD. Further, lower TBR at 10 months was positively associated with temperament dimensions conceptually related to ADHD at 2 years. TBR was not altered in infants with a family history of ASD. CONCLUSIONS: This is the first demonstration that alterations in TBR are present prior to behavioural symptoms of ADHD. However, these alterations manifest differently than those sometimes observed in older children with an ADHD diagnosis. Importantly, altered TBR was not seen in infants at elevated likelihood of developing ASD, suggesting a degree of specificity to ADHD. Taken together, these findings demonstrate that there are brain changes associated with a family history of ADHD observable in the first year of life.
Keywords
Original Article, Original Articles, Attention deficit hyperactivity disorder, theta–beta ratio, infancy, autism spectrum disorder, electroencephalography
Sponsorship
MRC (MR/T003057/1)
Identifiers
jcpp13563
External DOI: https://doi.org/10.1111/jcpp.13563
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334267
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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