Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine.
Authors
Todd, Oliver M
Fearon, Patricia
Mant, Jonathan
Hewitt, Jonathan
Warburton, Elizabeth A
Publication Date
2022-03Journal Title
Int J Stroke
ISSN
1747-4930
Publisher
SAGE Publications
Volume
17
Issue
3
Pages
251-259
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Evans, N. R., Todd, O. M., Minhas, J. S., Fearon, P., Harston, G. W., Mant, J., Mead, G., et al. (2022). Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine.. Int J Stroke, 17 (3), 251-259. https://doi.org/10.1177/17474930211034331
Abstract
Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings.
Keywords
Review, Frailty, stroke, inflammageing, rehabilitation
Identifiers
10.1177_17474930211034331
External DOI: https://doi.org/10.1177/17474930211034331
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334380
Rights
Licence:
https://creativecommons.org/licenses/by/4.0/
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