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dc.contributor.authorEvans, Nicholas
dc.contributor.authorTodd, Oliver M
dc.contributor.authorMinhas, Jatinder S
dc.contributor.authorFearon, Patricia
dc.contributor.authorHarston, George W
dc.contributor.authorMant, Jonathan
dc.contributor.authorMead, Gillian
dc.contributor.authorHewitt, Jonathan
dc.contributor.authorQuinn, Terence J
dc.contributor.authorWarburton, Liz
dc.date.accessioned2022-02-23T19:00:05Z
dc.date.available2022-02-23T19:00:05Z
dc.date.issued2022-03
dc.date.submitted2021-04-06
dc.identifier.issn1747-4930
dc.identifier.other10.1177_17474930211034331
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334380
dc.description.abstractFrailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings.
dc.languageen
dc.publisherSAGE Publications
dc.subjectReview
dc.subjectFrailty
dc.subjectstroke
dc.subjectinflammageing
dc.subjectrehabilitation
dc.titleFrailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine.
dc.typeArticle
dc.date.updated2022-02-23T19:00:05Z
prism.endingPage259
prism.issueIdentifier3
prism.publicationNameInt J Stroke
prism.startingPage251
prism.volume17
dc.identifier.doi10.17863/CAM.81796
dcterms.dateAccepted2021-07-02
rioxxterms.versionofrecord10.1177/17474930211034331
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2021-08-04
dc.contributor.orcidEvans, Nicholas [0000-0002-7640-4701]
dc.contributor.orcidMinhas, Jatinder S [0000-0002-0576-9105]
dc.contributor.orcidHarston, George W [0000-0003-4916-5757]
dc.contributor.orcidMant, Jonathan [0000-0002-9531-0268]
dc.contributor.orcidMead, Gillian [0000-0001-7494-2023]
dc.contributor.orcidQuinn, Terence J [0000-0003-1401-0181]
dc.identifier.eissn1747-4949
cam.issuedOnline2021-08-04
rioxxterms.freetoread.startdate2021-08-04
rioxxterms.freetoread.startdate2021-08-04


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