Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.
Authors
Douthwaite, Julie A
Brown, Christopher A
Ferdinand, John R
Sharma, Rahul
Elliott, Jane
Taylor, Molly A
Malintan, Nancy T
Duvoisin, Hannah
Hill, Thomas
Delpuech, Oona
Orton, Alexandra L
Pitt, Haidee
Kuenzi, Fred
Fish, Simon
Nicholls, David J
Cuthbert, Anna
Richards, Ian
Ratcliffe, Giles
Upadhyay, Abhishek
Marklew, Abigail
Hewitt, Craig
Ross-Thriepland, Douglas
Brankin, Christopher
Chodorge, Matthieu
Browne, Gareth
Mander, Palwinder K
DeWildt, Ruud M
Weaver, Shane
Smee, Penny A
van Kempen, Joost
Bartlett, Jon G
Allen, Paula M
Koppe, Emma L
Ashby, Charlotte A
Phipps, Julian D
Mehta, Nalini
Brierley, David J
Tew, David G
Leveridge, Melanie V
Baddeley, Stuart M
Goodfellow, Ian G
Green, Clive
Neely, Andy
Waddell, Ian
Rees, Steve
Maxwell, Patrick H
Pangalos, Menelas N
Howes, Rob
Clark, Roger
Publication Date
2022-02-24Journal Title
Sci Rep
ISSN
2045-2322
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Douthwaite, J. A., Brown, C. A., Ferdinand, J. R., Sharma, R., Elliott, J., Taylor, M. A., Malintan, N. T., et al. (2022). Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.. Sci Rep, 12 (1) https://doi.org/10.1038/s41598-022-06873-6
Abstract
On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate the testing capacity required. The Cambridge COVID-19 Testing Centre (CCTC) was established during April 2020 through collaboration between AstraZeneca, GlaxoSmithKline, and the University of Cambridge, with Charles River Laboratories joining the collaboration at the end of July 2020. The CCTC lab operation focussed on the optimised use of automation, introduction of novel technologies and process modelling to enable a testing capacity of 22,000 tests per day. Here we describe the optimisation of the laboratory process through the continued exploitation of internal performance metrics, while introducing new technologies including the Heat Inactivation of clinical samples upon receipt into the laboratory and a Direct to PCR protocol that removed the requirement for the RNA extraction step. We anticipate that these methods will have value in driving continued efficiency and effectiveness within all large scale viral diagnostic testing laboratories.
Keywords
Article, /631/1647/2163, /631/326/2521, article
Identifiers
s41598-022-06873-6, 6873
External DOI: https://doi.org/10.1038/s41598-022-06873-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334418
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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